Document Detail

Pallidal hyperintensity on magnetic resonance imaging in cirrhotic patients: clinical correlations.
MedLine Citation:
PMID:  1446893     Owner:  NLM     Status:  MEDLINE    
Patients with cirrhosis show increased signal intensity in the globus pallidus on T1-weighted magnetic resonance imaging of the brain. This abnormal appearance of the basal ganglia has been related to the severity of liver failure and to the presence of portal-systemic shunting, although its cause and clinical significance remain unknown. We prospectively assessed the metabolic, neurological and neuropsychological statuses of 30 stable cirrhotic patients and correlated these clinical variables with computed measurements of globus pallidus signals. Some metabolic variables denoting disease severity appeared to be significantly related to image changes, although the strongest association was found with plasma ammonia levels. After adjustment for ammonia level, on multiple regression analysis, the other variables were not significant. Furthermore, pallidal changes were associated with specific neurological symptoms and neurological functions, symptoms and functions that also had a significant correlation with ammonia levels. Our findings suggest that globus pallidus signal abnormality could arise as a marker of brain impairment related to hyperammonemia.
J Kulisevsky; J Pujol; J Balanzó; C Junqué; J Deus; A Capdevilla; C Villanueva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  16     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1382-8     Citation Subset:  IM    
Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Spain.
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MeSH Terms
Alanine Transaminase / blood
Ammonia / blood
Aspartate Aminotransferases / blood
Bilirubin / blood
Globus Pallidus / pathology*
Liver Cirrhosis / blood,  pathology*,  physiopathology
Magnetic Resonance Imaging / methods
Middle Aged
Neurologic Examination
Platelet Count
Regression Analysis
Serum Albumin / analysis
Reg. No./Substance:
0/Serum Albumin; 635-65-4/Bilirubin; 7664-41-7/Ammonia; EC Aminotransferases; EC Transaminase

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