| Palliative treatment of patients with colorectal cancer. | |
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MedLine Citation:
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PMID: 12705554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Metastatic colorectal cancer has a poor prognosis, and the majority of patients are left with palliative measures. The development seen using palliative chemotherapy is reviewed. MATERIAL AND METHODS: A systematic approach to the literature-based evidence was aimed at. RESULTS: The continuous improvements during the past 13-15 years have been documented in several large conclusive trials. At the end of the 1980s, the evidence that chemotherapy should be used at all was very limited, whereas presently most patients can be offered two lines of chemotherapy based upon good scientific evidence. Median survival has gradually improved from below 6 months to above 18 months in some recent trials. Several important issues remain to be solved, such as the best sequence of treatments, what regimens to use in various situations, when to start and when to stop if a response is seen, and whether cure may be possible in a small subset of patients. CONCLUSIONS: Progress has been rapid in advanced colorectal cancer. This is likely a result of well-designed trials in collaboration between academy and industry, showing a great interest in the disease. Future collaborations may hopefully introduce new treatment concepts, further improving outcome. |
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Authors:
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B Glimelius |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society Volume: 92 ISSN: 1457-4969 ISO Abbreviation: Scand J Surg Publication Date: 2003 |
Date Detail:
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Created Date: 2003-04-22 Completed Date: 2003-08-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101144297 Medline TA: Scand J Surg Country: Finland |
Other Details:
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Languages: eng Pagination: 74-83 Citation Subset: IM |
Affiliation:
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Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden. bengt.glimelius@onkologi.uu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimetabolites, Antineoplastic
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therapeutic use Camptothecin / analogs & derivatives*, therapeutic use Colorectal Neoplasms / drug therapy*, mortality, pathology* DNA Topoisomerases, Type I / antagonists & inhibitors Disease Progression Enzyme Inhibitors / therapeutic use Fluorouracil / therapeutic use Humans Leucovorin / therapeutic use Liver Neoplasms / drug therapy, secondary Palliative Care* Quinazolines / therapeutic use Survival Analysis Tegafur / therapeutic use Thiophenes / therapeutic use Thymidylate Synthase / antagonists & inhibitors Treatment Outcome Uracil / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 0/Enzyme Inhibitors; 0/Quinazolines; 0/Thiophenes; 100286-90-6/irinotecan; 112887-68-0/raltitrexed; 17902-23-7/Tegafur; 51-21-8/Fluorouracil; 58-05-9/Leucovorin; 66-22-8/Uracil; 7689-03-4/Camptothecin; EC 2.1.1.45/Thymidylate Synthase; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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