Document Detail

Palliative radiotherapy with electrons of appendicular osteosarcoma in 54 dogs.
MedLine Citation:
PMID:  15999538     Owner:  NLM     Status:  MEDLINE    
Radiotherapy is effective for the palliation of pain associated with primary and metastatic bony neoplasia in dogs and humans, but no standard treatment protocol has been established. The goal of this study was to evaluate a 3 x 8 Gy and a 4 x 6 Gy protocol using electrons with a betatron or linear accelerator for the treatment of appendicular osteosarcoma in 54 dogs. Thirty-three dogs received chemotherapy consisting of carboplatin IV concurrently with radiotherapy. Eighty-three % (n = 45) of the dogs experienced pain relief during or following treatment. The median duration of pain relief from treatment start was 53 days. In conclusion, both protocols are effective for palliation of clinical signs of canine appendicular osteosarcoma. The outcome reported here is similar to the results of other studies using Co photons. The use of chemotherapy did not improve the response to radiotherapy.
Fabienne Mueller; Valerie Poirier; Katja Melzer; Dagmar Nitzl; Malgorzata Roos; Barbara Kaser-Hotz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  19     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-07-07     Completed Date:  2005-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  713-6     Citation Subset:  IM    
Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zürich, Switzerland.
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MeSH Terms
Antineoplastic Agents
Bone Neoplasms / mortality,  pathology,  therapy,  veterinary*
Carboplatin / therapeutic use
Dog Diseases / drug therapy,  mortality,  pathology,  radiotherapy*
Electrons / therapeutic use*
Injections, Intravenous
Longevity / radiation effects
Osteosarcoma / mortality,  secondary,  therapy,  veterinary*
Pain / therapy
Palliative Care*
Radiotherapy, Adjuvant / veterinary
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents; 41575-94-4/Carboplatin

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