Document Detail

Palliative management of hilar cholangiocarcinoma.
MedLine Citation:
PMID:  16019208     Owner:  NLM     Status:  MEDLINE    
Around 80% of the patients with hilar cholangiocarcinoma are candidates for palliative management due to extensive co-morbidity for major surgery, metastases or advanced loco-regional disease. The primary aim of treatment is to provide biliary drainage with long-term relief from pruritus, cholangitis, pain and jaundice. Endoscopically placed self-expanding metallic biliary stent has low procedure-related complications and is probably the modality of choice for patients with unresectable tumour on preoperative assessment. Percutaneous biliary drainage has comparable results and is an alternative when endoscopic expertise is not available or has failed or there are multiple isolated segments with cholangitis. Surgical cholangiojejunostomy provides lasting biliary drainage but has limitations of associated morbidity and mortality. In the absence of high-quality studies, comparing these modalities the choice of biliary drainage procedure should be guided by the available local expertise. Other modalities of treatment like radiotherapy, chemotherapy and photodynamic therapy currently remain investigational.
D Singhal; T M van Gulik; D J Gouma
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Surgical oncology     Volume:  14     ISSN:  0960-7404     ISO Abbreviation:  Surg Oncol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-12-21     Revised Date:  2009-02-26    
Medline Journal Info:
Nlm Unique ID:  9208188     Medline TA:  Surg Oncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-74     Citation Subset:  IM    
Department of Surgery, Academic Medical Center, Amsterdam, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
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MeSH Terms
Bile Duct Neoplasms / classification,  diagnosis,  surgery*
Bile Ducts, Intrahepatic*
Cholangiocarcinoma / classification,  diagnosis,  surgery*
Digestive System Surgical Procedures
Drainage / methods*
Palliative Care*
Prosthesis Implantation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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