Document Detail


Palliative management of hilar cholangiocarcinoma.
MedLine Citation:
PMID:  16019208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Around 80% of the patients with hilar cholangiocarcinoma are candidates for palliative management due to extensive co-morbidity for major surgery, metastases or advanced loco-regional disease. The primary aim of treatment is to provide biliary drainage with long-term relief from pruritus, cholangitis, pain and jaundice. Endoscopically placed self-expanding metallic biliary stent has low procedure-related complications and is probably the modality of choice for patients with unresectable tumour on preoperative assessment. Percutaneous biliary drainage has comparable results and is an alternative when endoscopic expertise is not available or has failed or there are multiple isolated segments with cholangitis. Surgical cholangiojejunostomy provides lasting biliary drainage but has limitations of associated morbidity and mortality. In the absence of high-quality studies, comparing these modalities the choice of biliary drainage procedure should be guided by the available local expertise. Other modalities of treatment like radiotherapy, chemotherapy and photodynamic therapy currently remain investigational.
Authors:
D Singhal; T M van Gulik; D J Gouma
Related Documents :
12407338 - Improved survival in resected biliary malignancies.
16315338 - Endoscopic sphincterotomy and temporary internal stenting for bile leaks following comp...
15313688 - Surgical procedure and prognosis of hilar cholangiocarcinoma.
16401938 - Accuracy of ultrasonography in evaluation of level and cause of biliary obstruction: a ...
18185938 - Conversion rate in 300 laparoscopic rectal resections and its influence on morbidity an...
20733368 - The aesthetic repair of complete traumatic cleft earlobe with a three-flap method.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Surgical oncology     Volume:  14     ISSN:  0960-7404     ISO Abbreviation:  Surg Oncol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-12-21     Revised Date:  2009-02-26    
Medline Journal Info:
Nlm Unique ID:  9208188     Medline TA:  Surg Oncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-74     Citation Subset:  IM    
Affiliation:
Department of Surgery, Academic Medical Center, Amsterdam, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bile
Bile Duct Neoplasms / classification,  diagnosis,  surgery*
Bile Ducts, Intrahepatic*
Cholangiocarcinoma / classification,  diagnosis,  surgery*
Digestive System Surgical Procedures
Drainage / methods*
Endoscopy
Humans
Palliative Care*
Prosthesis Implantation
Stents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Difficulty demonstrating estradiol-mediated Erk1/2 phosphorylation in MCF-7 cells.
Next Document:  Synthesis of [18F]SU11248, a new potential PET tracer for imaging cancer tyrosine kinase.