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Palliative Treatment of Metastatic Colorectal Cancer: What is the Optimal Approach?
MedLine Citation:
PMID:  24293074     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Worldwide, colorectal cancer (CRC) is responsible for over 600,000 deaths annually and remains a significant public health concern. Because of therapeutic advancements over the past two decades, patients with metastatic CRC are living longer with an improved quality of life. This review will highlight recent trial evidence that improves outcomes for patients with metastatic disease. Topics will include the optimal use of first-line combination chemotherapy, bevacizumab in patients with advanced age or comorbidities, maintenance chemotherapy, first-line use of anti-EGFR therapies, first-line cetuximab versus bevacizumab, anti-angiogenic therapies past progression, and management of treatment-refractory disease. Clinical trial evidence will be presented, along with guidance on how to integrate recent evidence into clinical practice. Finally, this review will examine innovative drug development strategies, and will discuss potentially actionable targets identified by molecular testing.
Authors:
John H Strickler; Herbert I Hurwitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current oncology reports     Volume:  16     ISSN:  1534-6269     ISO Abbreviation:  Curr Oncol Rep     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888967     Medline TA:  Curr Oncol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, DUMC 2823, Durham, NC, 27710, USA, john.strickler@dm.duke.edu.
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