| Palliation of cyanotic congenital heart disease in infancy with E-type prostaglandins. | |
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MedLine Citation:
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PMID: 64317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin-E (PGE) infusions have been used in an attempt to increase ductal patency in 11 infants aged one to 99 days with cyanotic heart disease. PGE1 was used in nine infants and PGE2 in two. Five patients had pulmonary atresia, four extreme pulmonary stenosis, one Ebstein's anomaly and one simple transposition of the great arteries. All but the oldest infant showed a satisfactory increase in oxygen saturation (average 36%) attributed to dilatation of the ductus. The failure in one infant may have been due largely to hypoplasia of the left pulmonary artery. The only important side effect was apnea in one infant receiving PGE2. The efficacy of this form of treatment is confirmed in infants dependent on ductal patency for survival. PGE is an important asset in saving the lives of neonates requiring an aorticopulmonary shunt operation. The recommended starting dose is 0.1 mug/kg/min of PGE1 given by constant infusion. |
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Authors:
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J M Neutze; M B Starling; R B Elliott; B G Barratt-Boyes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 55 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 238-41 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Defects, Congenital
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drug therapy* Humans Infant Infant, Newborn Infusions, Parenteral Oxygen / blood Palliative Care Prostaglandins E / administration & dosage, therapeutic use* Pulmonary Circulation / drug effects Pulmonary Heart Disease / drug therapy Pulmonary Valve Stenosis / drug therapy Transposition of Great Vessels / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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