Document Detail


Palladium-catalyzed aerobic oxidative kinetic resolution of alcohols with an achiral exogenous base.
MedLine Citation:
PMID:  12968915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Substitution of exogenous (-)-sparteine for a more practical achiral base in the aerobic oxidative kinetic resolution of secondary alcohols is described. Carbonate bases are the most effective of those screened and allow for effective kinetic resolution of benzylic, allylic, and aliphatic substrates. The procedure was also successfully extended to the oxidative desymmetrization of meso diols.
Authors:
Sunil K Mandal; Matthew S Sigman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  68     ISSN:  0022-3263     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-12     Completed Date:  2004-03-18     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7535-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alcohols / chemistry*,  isolation & purification
Catalysis
Kinetics
Oxygen / chemistry
Palladium / chemistry
Sparteine / chemistry
Grant Support
ID/Acronym/Agency:
GM63540/GM/NIGMS NIH HHS; R01 GM063540/GM/NIGMS NIH HHS; R01 GM063540-05/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Alcohols; 298897D62S/Sparteine; 5TWQ1V240M/Palladium; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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