| Palivizumab utilization and compliance: trends in respiratory syncytial virus prophylaxis in Florida. | |
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MedLine Citation:
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PMID: 20223478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To analyze adherence to guidelines to prevent respiratory syncytial virus hospitalization and to a monthly immunoprophylaxis schedule in the absence of prior authorization requirements. STUDY DESIGN: Among Florida Medicaid fee-for-service recipients 0 to 2 years of age from the 1998/1999 season through the 2004/2005 season with available birth certificates, we identified indications for palivizumab prophylaxis based on claims data. At least 4 doses of palivizumab in the 5 core season-months were considered full season coverage. RESULTS: Of 302 101 children-seasons, 6089 were associated with 24 469 doses of palivizumab. In the 2004/2005 season, 73.6% of children with chronic lung disease received immunoprophylaxis, 67.6% children with gestational age <32 weeks, 37% with congenital heart disease, 26.4% with cystic fibrosis, and 19.4% with severe immunodeficiency. Multiple indications increased the likelihood for prophylaxis from 34.9% to 80.4%. Full season coverage was consistent across indications at approximately 70%. From the 1998/1999 season through the 2004/2005 season, 8038 doses were administered during 2051 children-seasons without any indication; mostly (69.6%) where premature children had exceeded the recommended age range for prophylaxis. CONCLUSIONS: High utilization rates were found in children with multiple indications, and compliance with a monthly schedule was consistently high. One third of doses were administered outside of guidelines, suggesting suboptimal utilization of resources in the absence of prior authorization. |
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Authors:
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Christian Hampp; Arwa S Saidi; Almut G Winterstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-10 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 953-9, 959.e1 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA. champp@ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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therapeutic use* Antiviral Agents / therapeutic use* Florida Guideline Adherence Humans Infant Infant, Newborn Medicaid Physician's Practice Patterns Respiratory Syncytial Virus Infections / epidemiology, prevention & control* Risk Factors United States |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antiviral Agents; 0/palivizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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