| Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity. | |
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MedLine Citation:
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PMID: 20664607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paleic acid (1), an antibiotic, was obtained from a fermentation broth of Paenibacillus sp. BMK771-AF3. The compound is a fatty acid (9Z,16R)-16-hydroxy-9-octadecenoic acid ((R)-16-hydroxyoleic acid), whose isolation required protection of its polar functional groups. Mosher esters of paleic acid yielded information on the absolute configuration of secondary alcohol, and well-resolved (1)H NMR peaks around the double bond suggested that olefin adopted a Z geometry. Paleic acid showed potent antibacterial activity and narrow spectrum against Mannheimia haemolytica with MIC values ranging between 0.78 and 1.56 microg ml(-1). |
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Authors:
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Ikuko Kurata; Maya Umekita; Tsutomu Sawa; Seiko Hattori; Chigusa Hayashi; Naoko Kinoshita; Yoshiko Homma; Masayuki Igarashi; Masa Hamada; Takumi Watanabe; Ryuichi Sawa; Hiroshi Naganawa; Yoshikazu Takahashi; Yuzuru Akamatsu |
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Publication Detail:
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Type: Journal Article Date: 2010-07-28 |
Journal Detail:
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Title: The Journal of antibiotics Volume: 63 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-09-16 Revised Date: 2011-02-24 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 519-23 Citation Subset: IM |
Affiliation:
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Institute of Microbial Chemistry, Tokyo, Shinagawa-ku, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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isolation & purification,
pharmacology* DNA, Bacterial / chemistry, genetics DNA, Ribosomal / chemistry, genetics Fatty Acids / chemistry, isolation & purification, metabolism, pharmacology* Fermentation Magnetic Resonance Spectroscopy Mannheimia haemolytica / drug effects* Microbial Sensitivity Tests Molecular Structure Oleic Acids / chemistry, isolation & purification, metabolism, pharmacology* Paenibacillus / chemistry*, classification, genetics, metabolism Pasteurella / drug effects* Phylogeny RNA, Ribosomal, 16S / genetics Sequence Analysis, DNA Soil Microbiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/DNA, Bacterial; 0/DNA, Ribosomal; 0/Fatty Acids; 0/Oleic Acids; 0/RNA, Ribosomal, 16S; 0/paleic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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