| Palatal zygomycosis: experience of 21 cases. | |
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MedLine Citation:
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PMID: 18248590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN: Retrospective report. SUBJECTS AND METHODS: This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a biopsy of the palatal lesion and autopsy. This study reports the treatment experience with amphotericin B alone and in combination with itraconazole and fluconazole. RESULTS: Twenty-one cases (18.75%) of zygomycosis with palatal involvement were included in the study, from a total of 112 cases screened. Mean age was 36.5 years, with 18 adults and three children. The associated pre-disposing factors were: ketoacidotic diabetes (five type-1 and 15 type-2), and acute leukaemia in one patient. The clinical varieties were as follows: 19 cases of rhinocerebral (RC) involvement and two disseminated cases. Palatal ulcers occurred in 3/21 early cases (14.3%) and in 16/21 cases after the nasal involvement. All patients received amphotericin B; in four patients, it was combined with itraconazole and four with fluconazole. Clinical and mycological cure was achieved in 4/21 patients (19.04%). CONCLUSION: Zygomycosis with palatal involvement occurs in around 18% of cases, usually associated with RC modalities; it has an acute and generally lethal course. |
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Authors:
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A Bonifaz; B Macias; F Paredes-Farrera; P Arias; R M Ponce; J Araiza |
Publication Detail:
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Type: Journal Article Date: 2008-02-01 |
Journal Detail:
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Title: Oral diseases Volume: 14 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2009-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: D |
Affiliation:
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Department of Mycology, Hospital General de México OD, Mexico GF. a_bonifaz@yahoo.com.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absidia
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isolation & purification Adolescent Adult Aged Amphotericin B / administration & dosage, therapeutic use Antifungal Agents / administration & dosage, therapeutic use Brain Diseases / microbiology Child Diabetic Ketoacidosis / complications Drug Combinations Female Fluconazole / administration & dosage, therapeutic use Humans Itraconazole / administration & dosage, therapeutic use Male Mouth Diseases / drug therapy, microbiology* Mucormycosis / diagnosis, drug therapy Nose Diseases / microbiology Opportunistic Infections / diagnosis Oral Ulcer / microbiology Palate / microbiology* Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications Retrospective Studies Rhizopus / isolation & purification Treatment Outcome Zygomycosis / diagnosis*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Drug Combinations; 1397-89-3/Amphotericin B; 84625-61-6/Itraconazole; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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