| Palatal development in Twirler mice. | |
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MedLine Citation:
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PMID: 11681996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models. |
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Authors:
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S G Gong; R L Eulenberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association Volume: 38 ISSN: 1055-6656 ISO Abbreviation: Cleft Palate Craniofac. J. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-29 Completed Date: 2002-01-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102566 Medline TA: Cleft Palate Craniofac J Country: United States |
Other Details:
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Languages: eng Pagination: 622-8 Citation Subset: D; IM |
Affiliation:
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Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA. sggong@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cephalometry Cleft Palate / embryology* Coloring Agents / diagnostic use Disease Models, Animal Embryo, Mammalian Embryonic and Fetal Development Eosine Yellowish-(YS) / diagnostic use Fluorescent Dyes / diagnostic use Gestational Age Hematoxylin / diagnostic use Homozygote Image Processing, Computer-Assisted Mice Mice, Mutant Strains Palate / embryology* Skull / embryology Statistics as Topic |
| Grant Support | |
ID/Acronym/Agency:
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R03 DE 12048-01/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Fluorescent Dyes; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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