Document Detail

Palatable food avoidance and acceptance learning with different stressors in female rats.
MedLine Citation:
PMID:  23380501     Owner:  NLM     Status:  MEDLINE    
Stress activates the hypothalamus-pituitary-adrenal (HPA) axis leading to the release of glucocorticoids (GC). Increased activity of the HPA axis and GC exposure has been suggested to facilitate the development of obesity and metabolic syndrome. Nonetheless, different stressors can produce distinct effects on food intake and may support different directions of food learning e.g. avoidance or acceptance. This study examined whether interoceptive (LiCl and exendin-4) and restraint stress (RS) support similar or distinct food learning. Female rats were exposed to different stressors after their consumption of a palatable food (butter icing). After four palatable food-stress pairings, distinct intakes of the butter icing were observed in rats treated with different stressors. Rats that received butter icing followed by intraperitoneal injections of LiCl (42.3mg/kg) and exendin-4 (10μg/kg) completely avoided the palatable food with subsequent presentations. In contrast, rats experiencing RS paired with the palatable food increased their consumption of butter icing across trials and did so to a greater degree than rats receiving saline injections. These data indicate that interoceptive and psychosocial stressors support conditioned food avoidance and acceptance, respectively. Examination of c-Fos immunoreactivity revealed distinct neural activation by interoceptive and psychosocial stressors that could provide the neural basis underlying opposite direction of food acceptance learning.
N-C Liang; M E Smith; T H Moran
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-01
Journal Detail:
Title:  Neuroscience     Volume:  235     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-08-30     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Antimanic Agents / pharmacology
Avoidance Learning / physiology*
Binge-Eating Disorder / psychology
Body Weight / physiology
Conditioning, Operant / physiology
Data Interpretation, Statistical
Eating / physiology*,  psychology*
Food Preferences / physiology*,  psychology*
Lithium Chloride / pharmacology
Peptides / pharmacology
Proto-Oncogene Proteins c-fos / metabolism
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological / psychology*
Venoms / pharmacology
Grant Support
Reg. No./Substance:
0/Antimanic Agents; 0/Peptides; 0/Proto-Oncogene Proteins c-fos; 0/Venoms; 9P1872D4OL/exenatide; G4962QA067/Lithium Chloride

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