Document Detail

Palatability of crushed ß-blockers, converting enzyme inhibitors and thiazides.
MedLine Citation:
PMID:  22486159     Owner:  NLM     Status:  MEDLINE    
WHAT IS KNOWN AND OBJECTIVES: A problem that often affects antihypertensive drugs is the lack of formulations appropriate for childhood. Parents, therefore, crush tablets and administer the antihypertensive drug mixed with solid food or a palatable drink. Because palatability is a major modulator of adherence to prescribed medication, the palatability of crushed ß-blockers, converting enzyme inhibitors and thiazides was assessed among adult volunteers.
METHODS: The palatability of crushed atenolol, bisoprolol, enalapril, lisinopril, ramipril, chlorthalidone and hydrochlorothiazide was evaluated by means of a facial hedonic scale among 20 volunteers. The calcium channel-blockers amlodipine and lercanidipine whose tastes are disliked and liked, respectively, by children were also tested. A concealed random allocation procedure was used.
RESULTS: The palatability scores assigned to chlorthalidone, hydrochlorothiazide and lisinopril were superior (P < 0·002) to those assigned to atenolol, bisoprolol, enalapril and ramipril. As with children, the palatability score of lercanidipine was superior to that of amlodipine (P < 0·002). The scores assigned to the various agents were similar in women and in men and were age-independent.
WHAT IS NEW AND CONCLUSION: Pulverized atenolol, bisoprolol, enalapril and ramipril are poor tasting. From the perspective of palatability, pulverized chlorthalidone, hydrochlorothiazide and lisinopril are preferable.
L Zgraggen; P B Faré; S A G Lava; G D Simonetti; E F Fossali; C Amoruso; M G Bianchetti
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-04-04
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  37     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-04     Completed Date:  2013-04-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  544-6     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Division of Pediatrics, Mendrisio and Bellinzona Hospitals, and University of Bern, Bern, Switzerland.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage*,  chemistry
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*,  chemistry
Antihypertensive Agents / administration & dosage*,  chemistry
Calcium Channel Blockers / administration & dosage
Child, Preschool
Medication Adherence
Middle Aged
Thiazides / administration & dosage*,  chemistry
Young Adult
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Thiazides

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