Document Detail

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.
MedLine Citation:
PMID:  17583796     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: Most studies of diet in glucose intolerance and type 2 diabetes have focused on intakes of fat, carbohydrate, fibre, fruits and vegetables. Instead, we aimed to compare diets that were available during human evolution with more recently introduced ones. METHODS: Twenty-nine patients with ischaemic heart disease plus either glucose intolerance or type 2 diabetes were randomised to receive (1) a Palaeolithic ('Old Stone Age') diet (n = 14), based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts; or (2) a Consensus (Mediterranean-like) diet (n = 15), based on whole grains, low-fat dairy products, vegetables, fruits, fish, oils and margarines. Primary outcome variables were changes in weight, waist circumference and plasma glucose AUC (AUC Glucose(0-120)) and plasma insulin AUC (AUC Insulin(0-120)) in OGTTs. RESULTS: Over 12 weeks, there was a 26% decrease of AUC Glucose(0-120) (p = 0.0001) in the Palaeolithic group and a 7% decrease (p = 0.08) in the Consensus group. The larger (p = 0.001) improvement in the Palaeolithic group was independent (p = 0.0008) of change in waist circumference (-5.6 cm in the Palaeolithic group, -2.9 cm in the Consensus group; p = 0.03). In the study population as a whole, there was no relationship between change in AUC Glucose(0-120) and changes in weight (r = -0.06, p = 0.9) or waist circumference (r = 0.01, p = 1.0). There was a tendency for a larger decrease of AUC Insulin(0-120) in the Palaeolithic group, but because of the strong association between change in AUC Insulin(0-120) and change in waist circumference (r = 0.64, p = 0.0003), this did not remain after multivariate analysis. CONCLUSIONS/INTERPRETATION: A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.
S Lindeberg; T Jönsson; Y Granfeldt; E Borgstrand; J Soffman; K Sjöström; B Ahrén
Related Documents :
20980356 - Association of abdominal visceral adiposity and thigh sarcopenia with changes of arteri...
25300286 - Influence of insulin and glargine on outgrowth and number of circulating endothelial pr...
25264116 - Contrasting associations of insulin resistance with diabetes, cardiovascular disease an...
25414156 - Renal function is associated with peak exercise capacity in adolescents with type 1 dia...
14976316 - Regulation of fasted blood glucose by resistin.
17986476 - Correlates of ace activity in macroalbuminuric type 2 diabetic patients treated with ch...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-06-22
Journal Detail:
Title:  Diabetologia     Volume:  50     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-07     Completed Date:  2008-01-07     Revised Date:  2008-02-29    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1795-807     Citation Subset:  IM    
Department of Medicine, Hs 32, University of Lund, SE-221 85, Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Area Under Curve
Blood Glucose / metabolism*
Body Mass Index
Diabetes Mellitus, Type 2 / blood,  diet therapy*
Diabetic Angiopathies / blood,  diet therapy
Diet, Mediterranean*
Glucose Tolerance Test
Hemoglobin A, Glycosylated / analysis
Insulin / blood
Middle Aged
Myocardial Ischemia / blood*,  diet therapy*
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A 10-s sprint performed prior to moderate-intensity exercise prevents early post-exercise fall in gl...
Next Document:  Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1bet...