Document Detail


Pairwise linkage analysis of 11 loci on human chromosome 4.
MedLine Citation:
PMID:  2894759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkages are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-( EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.
Authors:
J C Murray; K H Buetow; M Smith; L Carlock; A Chakravarti; R F Ferrell; L Gedamu; C Gilliam; R Shiang; C R DeHaven
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of human genetics     Volume:  42     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-13     Completed Date:  1988-04-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  490-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Iowa 52242.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping*
Chromosomes, Human, Pair 4*
Genetic Markers*
Humans
Linkage (Genetics)*
Polymorphism, Restriction Fragment Length
Grant Support
ID/Acronym/Agency:
HD20998/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

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