Document Detail


Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.
MedLine Citation:
PMID:  22018922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In C. elegans, homolog pairing and synapsis depend on pairing centers (PCs), special regions near one end of each chromosome that interact with the nuclear envelope (NE) and cytoplasmic microtubules. Here, we report that PCs are required for nuclear reorganization at the onset of meiosis. We demonstrate that PCs recruit the Polo-like kinase PLK-2 to induce NE remodeling, chromosome pairing, and synapsis. Recruitment of PLK-2 is also required to mediate a cell cycle delay and selective apoptosis of nuclei containing unsynapsed chromosomes, establishing a molecular link between these two quality control mechanisms. This work reveals unexpected functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny.
Authors:
Nicola C Harper; Regina Rillo; Sara Jover-Gil; Zoe June Assaf; Needhi Bhalla; Abby F Dernburg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-20
Journal Detail:
Title:  Developmental cell     Volume:  21     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-02-01     Revised Date:  2013-03-26    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  934-47     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3220, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / genetics*
Caenorhabditis elegans Proteins / genetics,  metabolism*
Chromosome Pairing / genetics*
Meiosis / genetics*
Nuclear Envelope / genetics,  metabolism
Protein-Serine-Threonine Kinases / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
5R00RR024110/RR/NCRR NIH HHS; R00 RR024110/RR/NCRR NIH HHS; R01 GM065591/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.21/polo-like kinase 2, C elegans
Comments/Corrections
Comment In:
Dev Cell. 2011 Nov 15;21(5):805-6   [PMID:  22075141 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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