Document Detail

Paired pulse ratio analysis of insulin-induced synaptic plasticity in the snail brain.
MedLine Citation:
PMID:  23393274     Owner:  NLM     Status:  Publisher    
Insulin's action in the brain can directly alter cognitive functioning. We have recently shown that molluscan insulin-related peptides are up-regulated following a conditioned taste aversion (CTA) training procedure. In addition, when mammalian insulin is superfused over the isolated Lymnaea central nervous system, it elicits long-term synaptic enhancement at the monosynaptic connection between the cerebral giant cell (CGC) and the buccal 1 (B1) motor neuron. This synaptic enhancement is thought to be a neural correlate of CTA. Here, we examined whether the observed changes in synaptic plasticity were the result of pre- and/or postsynaptic alterations using the paired pulse procedure. The paired pulse ratio was unaltered following insulin application, suggesting that insulin's effects on synaptic plasticity are mediated postsynaptically in the B1 motor neuron. Thus, it was suggested that postsynaptic changes need to be considered when insulin's actions on synaptic plasticity are examined.
Jun Murakami; Ryuichi Okada; Yutaka Fujito; Manabu Sakakibara; Ken Lukowiak; Etsuro Ito
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  The Journal of experimental biology     Volume:  -     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Tokushima Bunri University;
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