Document Detail


Paired Mg and Mg(B) ionization chambers for the measurement of boron neutron capture dose in neutron beams.
MedLine Citation:
PMID:  10587237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of the boron neutron capture (BNC) reaction to provide a dose enhancement in fast neutron therapy is currently under investigation at the Gershenson Radiation Oncology Center of Harper Hospital in Detroit, MI. The implementation of this treatment modality presents unique challenges in dosimetry. In addition to the measurement of photon and neutron doses in the mixed field, a measure of the thermal neutron flux and the associated boron neutron capture dose throughout the treatment volume is desired. A pair of small-volume magnesium ionization chambers has been constructed with the aim of providing this information. One of the chambers, denoted the Mg(B) chamber, is lined with a boron-loaded foil. The ionization response of this chamber has been calibrated in terms of BNC dose per ppm loading of 10B. These paired chambers can be used to map the local BNC response in neutron beams. From this data and an estimation of the boron concentration in the tumor and normal tissue, the boron neutron capture enhancement may be evaluated.
Authors:
J Burmeister; C Kota; M Yudelev; R L Maughan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Medical physics     Volume:  26     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-17     Completed Date:  1999-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2482-7     Citation Subset:  IM    
Affiliation:
Gershenson Radiation Oncology Center, Karmanos Cancer Institute, Harper Hospital and Wayne State University, Detroit, Michigan 48201, USA. burmeist@kci.wayne.edu]
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MeSH Terms
Descriptor/Qualifier:
Boron*
Boron Neutron Capture Therapy / instrumentation*,  methods
Calibration
Equipment Design
Phantoms, Imaging
Radiotherapy Dosage / standards*
Reproducibility of Results
Chemical
Reg. No./Substance:
7440-42-8/Boron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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