Document Detail


Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying protein-protein interactions.
MedLine Citation:
PMID:  23207368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.
Authors:
Yurii S Moroz; Wolfgang Binder; Patrik Nygren; Gregory A Caputo; Ivan V Korendovych
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-05-21     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  490-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Calmodulin / chemistry,  metabolism
Fluorescence Resonance Energy Transfer
Fluorescent Dyes / chemistry
Methionine / chemistry
Myosin-Light-Chain Kinase / chemistry,  metabolism
Protein Binding
Protein Interaction Mapping
Proteins / chemistry*,  metabolism
Tryptophan / chemistry,  metabolism*
Grant Support
ID/Acronym/Agency:
1R15GM094330/GM/NIGMS NIH HHS; R15 GM094330/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Calmodulin; 0/Fluorescent Dyes; 0/Proteins; 8DUH1N11BX/Tryptophan; AE28F7PNPL/Methionine; EC 2.7.11.18/Myosin-Light-Chain Kinase
Comments/Corrections

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