| Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying protein-protein interactions. | |
MedLine Citation:
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PMID: 23207368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them. |
Authors:
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Yurii S Moroz; Wolfgang Binder; Patrik Nygren; Gregory A Caputo; Ivan V Korendovych |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 49 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-12 Completed Date: 2013-05-21 Revised Date: 2014-01-23 |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 490-2 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calmodulin
/
chemistry,
metabolism Fluorescence Resonance Energy Transfer Fluorescent Dyes / chemistry Methionine / chemistry Myosin-Light-Chain Kinase / chemistry, metabolism Protein Binding Protein Interaction Mapping Proteins / chemistry*, metabolism Tryptophan / chemistry, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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1R15GM094330/GM/NIGMS NIH HHS; R15 GM094330/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Fluorescent Dyes; 0/Proteins; 8DUH1N11BX/Tryptophan; AE28F7PNPL/Methionine; EC 2.7.11.18/Myosin-Light-Chain Kinase |
| Comments/Corrections | |
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