| Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. | |
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MedLine Citation:
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PMID: 9675625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt. The aim of the present study was to investigate whether such an abnormal response to morphine challenge is entirely dependent on opioid receptor activation. A role for excitatory amino acids and gamma-aminobutyric acid has been proposed on the basis of the effect of diazepam. As opposed to naloxone, this gamma-aminobutyric acid agonist was found to inhibit the adverse effects of low doses of morphine in migraine sufferers, while at the same time being able to almost abolish morphine-induced miosis in subjects who underwent a short-lasting chronic pretreatment. The capacity of diazepam either to control the adverse effects of morphine or to induce well-being in subjects known to suffer from a central neurogenic pain such as migraine, is noteworthy even regarding the clinical treatment of other painful conditions, such as deafferentation pain, which is known to be not satisfactorily treated by using morphine. |
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Authors:
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M Nicolodi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 18 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1998 |
Date Detail:
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Created Date: 1998-10-15 Completed Date: 1998-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 79-85 Citation Subset: IM |
Affiliation:
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Interuniversity Centre of Neurochemistry, Unit of Florence University, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Diazepam / pharmacology Double-Blind Method Excitatory Amino Acids / metabolism* Humans Migraine Disorders / drug therapy, metabolism* Morphine / administration & dosage, adverse effects, pharmacology* Naloxone / pharmacology Narcotic Antagonists / pharmacology Narcotics / administration & dosage, adverse effects, pharmacology* Pain / metabolism Receptors, Opioid / drug effects, metabolism gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acids; 0/Narcotic Antagonists; 0/Narcotics; 0/Receptors, Opioid; 439-14-5/Diazepam; 465-65-6/Naloxone; 56-12-2/gamma-Aminobutyric Acid; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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