Document Detail

Pain reduction by fibrin sealant in older children and adult tonsillectomy.
MedLine Citation:
PMID:  15933528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Because tonsillectomy is a painful procedure in adults, this study was performed to see whether the addition of fibrin sealant (Tisseel) to the tonsillar fossa at the completion of tonsillectomy would reduce pain in adults and allow them to return to work sooner. STUDY DESIGN: Forty adult patients over the age of 12 were entered into a prospective randomized study to see whether the addition of fibrin sealant (Tisseel) to the tonsillar fossa at the completion of tonsillectomy for recurrent tonsillitis would reduce the time the patient needed to take narcotic analgesics after surgery. METHODS: Fifteen adults had a traditional complete tonsillectomy by means of a needle point Bovie and served as a control group. Twenty-five (adults had the same procedure with the addition of Tisseel to see how long they required narcotic analgesics postoperatively and when they were able to resume normal activities. RESULTS: The control group took narcotics for an average of 10.3 days, whereas the addition of Tisseel reduced the time to 8.16 days (P = .0058). This significant reduction of time allowed adults to return to work and other activities sooner. CONCLUSION: Because the time required to return to work is often of paramount interest to patients having surgery, Tisseel should be considered a safe addition to older children and adult tonsillectomy in patients who are not allergic to bovine products because it will allow an earlier return to normal activities.
Michael H Stevens; Daniel C Stevens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Laryngoscope     Volume:  115     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2005-06-28     Revised Date:  2006-01-20    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-6     Citation Subset:  IM    
Division of Otolaryngology, University Of Utah School Of Medicine, Salt Lake City, Utah 84106, USA.
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MeSH Terms
Analgesia / methods*
Fibrin Tissue Adhesive / therapeutic use*
Narcotics / administration & dosage
Pain, Postoperative / drug therapy*
Prospective Studies
Tissue Adhesives*
Tonsillectomy* / rehabilitation
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Narcotics; 0/Tissue Adhesives
Comment In:
Laryngoscope. 2005 Oct;115(10):1899; author reply 1900   [PMID:  16222220 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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