Document Detail

Pain provocation test in peptic duodenitis.
MedLine Citation:
PMID:  6315525     Owner:  NLM     Status:  MEDLINE    
Controversy exists as to whether or not duodenitis alone can cause peptic ulcer symptoms. A modified provocation perfusion test has been performed in 10 symptomatic patients with duodenitis confirmed by endoscopy and histology. The test was conducted without the patient being aware of whether 0.1 N hydrocholoric acid, normal saline, or 8.5% sodium bicarbonate was being perfused directly on the area of duodenitis through the endoscopic irrigation cannula at a fixed rate of 10 ml/min for 10 min. The test was also performed in eight patients with dyspepsia alone and in five patients with chronic duodenal ulceration. Intraduodenal infusion of acid reproduced the epigastric pain in all patients with peptic duodenitis and duodenal ulcer patients, including the feeling of nausea in several which was partially relieved by bicarbonate infusion. In patients with dyspepsia but no peptic duodenitis, the symptoms were not reproduced. It would appear that "peptic duodenitis" can cause symptoms and that this "pain provocation test" may prove useful in its diagnosis.
S N Joffe; J N Primrose
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  29     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-4     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / diagnostic use*
Duodenitis / diagnosis*
Hydrochloric Acid / diagnostic use*
Pain / etiology*
Sodium Bicarbonate
Sodium Chloride / diagnostic use
Reg. No./Substance:
0/Bicarbonates; 144-55-8/Sodium Bicarbonate; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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