Document Detail

Pain management in the last six months of life among women who died of ovarian cancer.
MedLine Citation:
PMID:  17196904     Owner:  NLM     Status:  MEDLINE    
Previous studies indicate that the symptoms of many dying cancer patients are undertreated and many suffer unnecessary pain. We obtained data retrospectively from three large health maintenance organizations, and examined the analgesic drug therapies received in the last six months of life by women who died of ovarian cancer between 1995 and 2000. Subjects were identified through cancer registries and administrative data. Outpatient medications used during the final six months of life were obtained from pharmacy databases. Pain information was obtained from medical charts. We categorized each medication based on the World Health Organization classification for pain management (mild, moderate, or intense). Of the 421 women, only 64 (15%) had no mention of pain in their charts. The use of medications typically prescribed for moderate to severe pain ("high intensity" drugs) increased as women approached death. At 5-6 months before death, 55% of women were either on no pain medication or medication generally used for mild pain; only 9% were using the highest intensity regimen. The percentage on the highest intensity regimen (drugs generally used for severe pain) increased to 22% at 3-4 months before death and 54% at 1-2 months. Older women (70 or older) were less likely to be prescribed the highest intensity medication than those under age 70 (44% vs. 70%, P<0.001). No differences were found in the use of the high intensity drugs by race, marital status, year of diagnosis, stage of disease, or comorbidity. Our finding that only 54% of women with pain were given high intensity medication near death indicates room for improvement in the care of ovarian cancer patients at the end of life.
Sharon J Rolnick; Jody Jackson; Winnie W Nelson; Amy Butani; Lisa J Herrinton; Mark Hornbrook; Christine Neslund-Dudas; Don J Bachman; Steven S Coughlin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  33     ISSN:  0885-3924     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-03-20     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-31     Citation Subset:  IM    
HealthPartners Research Foundation, Minneapolis, Minnesota 55440, USA.
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MeSH Terms
Analgesics / therapeutic use*
Middle Aged
Ovarian Neoplasms / complications*
Pain / drug therapy*,  etiology
Retrospective Studies
Terminal Care
Grant Support
200-2001-00117MC2-08//PHS HHS; 5U19 CA079689/CA/NCI NIH HHS; U19 CA079689-01/CA/NCI NIH HHS
Reg. No./Substance:

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