Document Detail

Pain levels within 24 hours after UFE: a comparison of morphine and fentanyl patient-controlled analgesia.
MedLine Citation:
PMID:  18797963     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to assess the presence and severity of pain levels during 24 h after uterine fibroid embolization (UFE) for symptomatic leiomyomata and compare the effectiveness and adverse effects of morphine patient-controlled analgesia (PCA) versus fentanyl PCA. We carried out a prospective, nonrandomized study of 200 consecutive women who received UFE and morphine or fentanyl PCA after UFE. Pain perception levels were obtained on a 0-10 scale for the 24-h period after UFE. Linear regression methods were used to determine pain trends and differences in pain trends between two groups and the association between pain scores and patient covariates. One hundred eighty-five patients (92.5%) reported greater-than-baseline pain after UFE, and 198 patients (99%) required IV opioid PCA. One hundred thirty-six patients (68.0%) developed nausea during the 24-h period. Seventy-two patients (36%) received morphine PCA and 128 (64%) received fentanyl PCA, without demographic differences. The mean dose of morphine used was 33.8 +/- 26.7 mg, while the mean dose of fentanyl was 698.7 +/- 537.4 lg. Using this regimen, patients who received morphine PCA had significantly lower pain levels than those who received fentanyl PCA (p \ 0.0001). We conclude that patients develop pain requiring IV opioid PCA within 24 h after UFE. Morphine PCA is more effective in reducing post-uterine artery embolization pain than fentanyl PCA. Nausea is a significant adverse effect from opioid PCA.
Hyun S Kim; Gregory J Czuczman; Wanda K Nicholson; Luu D Pham; Jeffrey M Richman
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-17
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  31     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-07     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1100-7     Citation Subset:  IM    
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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MeSH Terms
Analgesia, Patient-Controlled / methods*
Analgesics, Opioid / therapeutic use*
Fentanyl / therapeutic use*
Leiomyomatosis / therapy*
Magnetic Resonance Imaging
Middle Aged
Morphine / therapeutic use*
Pain / drug therapy*,  etiology*
Pain Measurement
Prospective Studies
Regression Analysis
Uterine Artery Embolization / adverse effects*
Uterine Neoplasms / therapy*
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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