| Pain in photodynamic therapy: mechanism of action and management strategies. | |
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MedLine Citation:
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PMID: 22892763 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Photodynamic therapy involves administration of a photosensitizing drug and its subsequent activation by irradiation with a light source at wavelengths matching the absorption spectrum of the photosensitizer. In many countries around the world, topical photodynamic therapy has been approved for treatment of cutaneous oncologic conditions such as actinic keratosis, Bowen's disease, and superficial basal cell carcinoma. Multicenter, randomized, controlled studies have confirmed its efficacy and superior cosmetic outcomes compared to conventional therapies. Nevertheless, this therapeutic method presents some adverse effects, such as erythema, edema, pigmentation, pustules, and pain. There is no doubt that pain is the most severe of the adverse effects, being sometimes responsible for definitive treatment interruption. The pain mechanism has not yet been fully understood, which makes complete pain control a challenge to be conquered. In spite of that, this literature review presents some useful pain management strategies as well as the most important pain-related factors in photodynamic therapy. |
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Authors:
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Yuri Nogueira Chaves; Luis Antônio Torezan; Ane Beatriz Mautari Niwa; José Antônio Sanches Junior; Ciro Festa Neto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anais brasileiros de dermatologia Volume: 87 ISSN: 1806-4841 ISO Abbreviation: An Bras Dermatol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067662 Medline TA: An Bras Dermatol Country: Brazil |
Other Details:
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Languages: eng Pagination: 521-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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