Document Detail

Pain threshold improvement for chronic hyperacusis patients in a prospective clinical study.
MedLine Citation:
PMID:  19821704     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate if laser therapy in combination with pulsed electromagnetic field therapy/repetitive transcranial magnetic stimulation (rTMS) and the control of reactive oxygen species (ROS) would lead to positive treatment results for hyperacusis patients.
BACKGROUND DATA: Eight of the first ten patients treated for tinnitus, who were also suffering from chronic hyperacusis, claimed their hyperacusis improved. Based upon that, a prospective, unblinded, uncontrolled clinical trial was planned and conducted. ROS and hyperacusis pain thresholds were measured.
MATERIALS AND METHODS: Forty-eight patients were treated twice a week with a combination of therapeutic laser, rTMS, and the control and adjustment of ROS. A magnetic field of no more than 100 microT was oriented behind the outer ear, in the area of the mastoid bone. ROS were measured and controlled by administering different antioxidants. At every treatment session, 177-504 J of laser light of two different wavelengths was administered toward the inner ear via meatus acusticus.
RESULTS: The improvements were significantly better in the verum group than in a placebo group, where 40% of the patients were expected to have a positive treatment effect. The patients in the long-term follow-up group received significantly greater improvements than the patients in the short-term follow-up group.
CONCLUSION: The treatment is effective in treating chronic hyperacusis.
Michael Zazzio
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  28     ISSN:  1557-8550     ISO Abbreviation:  Photomed Laser Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-10-01     Revised Date:  2012-08-28    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-7     Citation Subset:  IM    
Audio Laser-Kliniken, Flygeln, Hovmantorp, Sweden.
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MeSH Terms
Aged, 80 and over
Chronic Disease
Combined Modality Therapy
Hyperacusis / physiopathology*,  therapy*
Laser Therapy
Middle Aged
Pain Threshold*
Prospective Studies
Reactive Oxygen Species
Transcranial Magnetic Stimulation
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Reactive Oxygen Species
Comment In:
Photomed Laser Surg. 2012 Jul;30(7):400; author reply 401-2   [PMID:  22742680 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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