Document Detail

Pain management after elective hallux valgus surgery: a prospective randomized double-blind study comparing etoricoxib and tramadol.
MedLine Citation:
PMID:  20584877     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pain is a common complaint after day surgery, and there is still a controversy surrounding the use of selective cyclooxygenase-2 (COX-2) inhibitors. In the present prospective, randomized, double-blind study we compared pain management with a selective (COX-2) inhibitor (etoricoxib) with pain management using sustained-release tramadol after elective hallux valgus surgery. METHODS: One hundred ASA 1 to 2 female patients were randomized into 2 groups of 50 patients each; oral etoricoxib 120 mg x 1 x IV + 90 mg x 1 x day V-VII and oral tramadol sustained-release 100 mg x 2 x VII. Pain, pain relief, satisfaction with pain management, and need for rescue medication were evaluated during the first 7 postoperative days. A computed tomography scan evaluating bone healing was performed 12 weeks after surgery. A clinical evaluation of outcome (healing, mobility, and patient-assessed satisfaction) was performed 16 weeks after surgery. RESULTS: Two patients withdrew before discharge from the hospital. Ninety-eight patients, 81 ASA 1 and 17 ASA 2 (82 nonsmokers and 14 smokers), mean age 49 years (19-65), weight 64 (47-83) kg, and height 167 (154-183) cm were evaluated. Overall pain was well managed, but the mean visual analog scale (VAS) was significantly lower among etoricoxib patients evaluated during the entire 7-day period studied (12.5 + or - 8.3 vs. 17.3 + or - 11, P < 0.05). patient's grading of pain relief (92 + or - 12 vs. 85 + or - 15, P < 0.05) and satisfaction with pain medication (47/49 vs. 39/49, P < 0.05) was higher among etoricoxib patients. Patients receiving tramadol reported significantly more side effects. Six patients, all in the tramadol group, discontinued the study because of side effects (P < 0.05). At 14-day follow-up 1 patient in the etoricoxib group and 5 patients in the tramadol group exhibited minor irritation in the wound area. The 12-week computed tomography scan showed good healing in 82 patients, 43 in the etoricoxib group, and 39 in the tramadol group. The study found ongoing healing in 11 patients, 4 in the etoricoxib group and 7 in the tramadol group. The 16-week patient-assessed Health Profile Quality of life revealed high patient satisfaction overall; 47 patients in each study group rated the outcome as satisfactory and the mean change in the patient-assessed quality of life VAS score was 6.2 and 2.6 for the etoricoxib and tramadol groups, respectively. Clinical follow-up at 16 weeks showed high functionality and no signs or symptoms of improper healing in any patient. CONCLUSION: Etoricoxib was found to be more effective and associated with fewer side effects in comparison with tramadol sustained release as a component of multimodel analgesia after elective hallux valgus surgery. There were no signs of impaired wound or bone healing associated with the use of etoricoxib.
Metha Brattwall; Ibrahim Turan; Jan Jakobsson
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-28
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  111     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-9     Citation Subset:  AIM; IM    
Foot & Ankle Surgical Centre, Storängsvägen 10, 11542 Stockholm, Sweden.
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MeSH Terms
Administration, Oral
Analgesia / methods*
Analgesics, Opioid / administration & dosage,  adverse effects,  therapeutic use*
Chi-Square Distribution
Cyclooxygenase 2 Inhibitors / administration & dosage,  adverse effects,  therapeutic use*
Delayed-Action Preparations
Double-Blind Method
Hallux Valgus / radiography,  surgery*
Middle Aged
Orthopedic Procedures*
Pain Measurement
Pain, Postoperative / prevention & control*
Patient Satisfaction
Prospective Studies
Pyridines / administration & dosage,  adverse effects,  therapeutic use*
Quality of Life
Sulfones / administration & dosage,  adverse effects,  therapeutic use*
Surgical Procedures, Elective
Time Factors
Tramadol / administration & dosage,  adverse effects,  therapeutic use*
Treatment Outcome
Wound Healing
Reg. No./Substance:
0/Analgesics, Opioid; 0/Cyclooxygenase 2 Inhibitors; 0/Delayed-Action Preparations; 0/Pyridines; 0/Sulfones; 202409-33-4/etoricoxib; 27203-92-5/Tramadol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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