Document Detail

Pagetoid spread into the rete testis by testicular tumours.
MedLine Citation:
PMID:  8045529     Owner:  NLM     Status:  MEDLINE    
Germ cell neoplasia of the testis can spread into the rete testis in a pagetoid manner, but this is less often recognized than vascular invasion or direct spread into the tunica albuginea. The rete testis was studied in 71 orchidectomy specimens: 47 with an untreated germ cell tumour, 18 with germ cell neoplasia after treatment with chemotherapy, and six with other tumours. Pagetoid spread into the rete testis was seen in 14 of the 47 cases of germ cell tumour. The cytology of the infiltrating cells was that of intratubular germ cell neoplasia. Hyperplasia of the rete testis was seen in six cases. In three of the four testes with untreated germ cell neoplasia and hyperplasia of the rete, neoplastic cells were seen in the hyperplastic rete epithelium. The two testes with extensive pagetoid involvement of the rete testis by intratubular germ cell neoplasia both had associated hyperplasia of the rete testis. Two of the 18 testes with germ cell neoplasia after chemotherapy had focal hyperplasia. Pagetoid involvement of the rete testis by intratubular germ cell neoplasia is common and may be a cause of hyperplasia of the rete testis.
A H Lee; J M Theaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  24     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-30     Completed Date:  1994-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Department of Histopathology, Southampton General Hospital, UK.
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MeSH Terms
Neoplasm Invasiveness / pathology
Neoplasms, Germ Cell and Embryonal / pathology*,  therapy
Rete Testis / pathology*
Retrospective Studies
Seminoma / pathology
Teratoma / pathology
Testicular Neoplasms / pathology*,  therapy
Comment In:
Histopathology. 1995 Oct;27(4):391-2   [PMID:  8847075 ]

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