Document Detail

Paget-Schroetter syndrome associated with FV:Q506 and prothrombin 20210A--a case report.
MedLine Citation:
PMID:  10451238     Owner:  NLM     Status:  MEDLINE    
Effort thrombosis of the axillary-subclavian vein (Paget-Schroetter syndrome) develops usually secondary to heavy arm exertion. An underlying chronic venous compressive anomaly at the thoracic outlet or intimal damage of the axillary vein following forceful hyperabduction, external rotation of the shoulder joint has been proposed to explain the pathophysiology of this thrombosis. This condition is usually not attributed to an underlying hypercoagulability such as deficiency of natural coagulation inhibitors. Here, the authors present a case with thrombosis of the axillary-subclavian vein following an effort, with factor V Leiden and prothrombin 20210A mutations. Both factor V Leiden and the genetic variant in the prothrombin gene have been shown to confer an increased risk for venous thrombosis. Although rare, effort thrombosis may develop in a patient with hereditary thrombophilia, so laboratory evaluation should include the common causes of thrombosis.
N Sayinalp; O I Ozcebe; S Kirazli; R Doğan; S V Dündar; A Gürgey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  50     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-30     Completed Date:  1999-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-92     Citation Subset:  IM    
Department of Hematology, Hacettepe University Medical School, Ankara, Turkey.
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MeSH Terms
Anticoagulants / therapeutic use
Axillary Vein* / radiography
Factor V / genetics*,  metabolism
Point Mutation*
Polymerase Chain Reaction
Prothrombin / genetics*,  metabolism
Subclavian Vein* / radiography
Venous Thrombosis / blood,  genetics*,  radiography,  therapy
Warfarin / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 0/factor V Leiden; 81-81-2/Warfarin; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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