Document Detail

Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats.
MedLine Citation:
PMID:  11086710     Owner:  NLM     Status:  MEDLINE    
Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the target tissues of the liver and bladder, and also in circulating leucocytes. This work investigated how paeonol affects arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented showing that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylation. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with paeonol, the lymphocyte and monocyte cultures indicated that paeonol did increase 2-aminofluorene and p-aminobenzoic acid acetylations.
H L Chang; C F Hung; C C Yeh; W C Chang; J G Chung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytobios     Volume:  103     ISSN:  0011-4529     ISO Abbreviation:  Cytobios     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-03-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0207227     Medline TA:  Cytobios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Department of Pharmacology, China Medical College, Taichung, Taiwan, Republic of China.
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MeSH Terms
4-Aminobenzoic Acid / metabolism*,  pharmacology
Acetophenones / pharmacology*
Acetylation / drug effects
Arylamine N-Acetyltransferase / drug effects*,  metabolism
Carcinogens / metabolism*,  pharmacology
Cytosol / drug effects,  metabolism
Dose-Response Relationship, Drug
Ellagic Acid / pharmacology
Fluorenes / metabolism*,  pharmacology
Leukocytes, Mononuclear / cytology,  drug effects*,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Acetophenones; 0/Carcinogens; 0/Fluorenes; 150-13-0/4-Aminobenzoic Acid; 153-78-6/2-aminofluorene; 476-66-4/Ellagic Acid; 552-41-0/paeonol; EC N-Acetyltransferase

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