| Paeonol Attenuates Microglia-Mediated Inflammation and Oxidative Stress-Induced Neurotoxicity in Rat Primary Microglia and Cortical Neurons. | |
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MedLine Citation:
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PMID: 22089194 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Inflammation and oxidative stress play important roles in the pathogenesis of neurodegenerative disorders such as stroke, traumatic injury, Parkinson's disease and Alzheimer's disease. Paeonol, a natural compound extracted from Moutan Cortex, is a potent anti-inflammatory and anti-oxidative agent. The aim of this study was to investigate the neuroprotective mechanisms of paeonol on lipopolysaccharides (LPS)-induced inflammation in rat primary microglia and 6-hydroxydopamine (6-OHDA)-induced oxidative damage in cortical neurons. In LPS-treated microglia, paeonol attenuated the overexpression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to the decrease of nitric oxide (NO) and prostaglandin E2 (PGE2) production, respectively. Paeonol also suppressed LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK), and Jun N-terminal kinase (JNK). In addition, LPS-stimulated NADPH oxidase activation, and reactive oxygen species (ROS) production were attenuated by paeonol. Paeonol-induced upregulation of heme oxygenase-1 (HO-1) was also observed. Moreover, paeonol attenuated LPS-treated microglia culture medium (LCM)-induced neuron cells death. Post-treatment with paeonol also reduced inflammatory responses in LPS-activated microglia and increased cell viability in LCM-treated neurons. Furthermore, in 6-OHDA-treated cortical neurons, paeonol not only decreased ROS production but also increased cell viability, superoxide dismutase (SOD) activity and the anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) expression. Taken together, the present results suggest that paeonol might be a potential neuroprotective agent via inhibiting microglia-mediated inflammation and oxidative stress-induced neuronal damage. |
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Authors:
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Yu-Ting Tseng; Ya-Yun Hsu; Yu-Tzu Shih; Yi-Ching Lo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Graduate Institute of Natural Products, †Graduate Institute of Medicine and ‡Department of Pharmacology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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