Document Detail


Paediatric outcomes following intrauterine exposure to serotonin reuptake inhibitors - a systematic review.
MedLine Citation:
PMID:  21893008     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The use of serotonine reuptake inhibitors (SRIs) is increasing among Danish pregnant women. This systematic review addresses the potential adverse effects on the foetus and child of maternal SRI medication. The literature indicates a slightly increased risk of cardiovascular malformations and persistent pulmonary hypertension of the new-born, while evidence regarding the risk of preterm labour, low birth weight, low Apgar score, prolonged QT interval and miscarriage is less clear. An estimated 20-30% of infants will have neonatal symptoms following intrauterine SRI exposure. The symptoms may be caused by SRI withdrawal, toxicity or their overlap, but symptom aetiology basically remains controversial. The infants may exhibit neurological, gastrointestinal, autonomic, endocrine or respiratory symptoms. Although the symptoms are self-limited, the families may be seriously affected. In general, studies do not address this important aspect. Evidence concerning long-term effects is surprisingly sparse and many studies have important methodological limitations. However, present evidence does not convincingly indicate detrimental long-term effects. Until sufficient safety studies have been carried out, SRI must be used with caution in pregnancy and every treatment of the pregnant woman should be thoroughly considered.
Authors:
Jesper Fenger-Grøn; Morten Thomsen; Kristian Skytte Andersen; Rasmus Gaardskær Nielsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Danish medical bulletin     Volume:  58     ISSN:  1603-9629     ISO Abbreviation:  Dan Med Bull     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066040     Medline TA:  Dan Med Bull     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  A4303     Citation Subset:  IM    
Affiliation:
Pædiatrisk Afdeling, Sygehus Lillebælt, 6000 Kolding, Denmark. jfg@grejsdalen.dk.
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