Document Detail


Paclitaxel and sirolimus eluting stents versus bare metal stents: long-term risk of stent thrombosis and other outcomes. From the Western Denmark Heart Registry.
MedLine Citation:
PMID:  20542774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Stent thrombosis is a serious complication of percutaneous coronary intervention (PCI). We examined the incidence of stent thrombosis and other outcomes in patients treated with PCI and paclitaxeleluting stents (PES), sirolimus-eluting stents (SES) or bare-metal stents (BMS). METHODS AND RESULTS: All patients who underwent PES, SES or BMS implantation from January 2002 to June 2005 were identified in the population-based Western Denmark Heart Registry. All were followed for 36 months. Cox regression analysis was used to estimate relative risk (RR), controlling for covariates. A total of 12,374 patients were treated with stents: 1,298 with PES, 2,202 with SES and 8,847 with BMS. The three-year incidence of definite stent thrombosis was similar in the DES group (1.1%) and in the BMS group (0.7%) (adjusted relative risk [RR]: 1.24; 95% confidence interval [CI]: 0.85-1.81). Very late definite stent thrombosis occurred more frequently in DES-treated patients (adjusted RR: 2.89, 95% CI: 1.48- 5.65). The three-year mortality rate did not differ significantly between the two groups. Target lesion revascularisation (TLR) was lower in DES-treated patients than in BMS-treated patients (adjusted RR: 0.71, 95% CI: 0.63-0.81). CONCLUSIONS: An increased risk of very late definite stent thrombosis was observed in DES-treated patients compared with BMS-treated patients, but a similar mortality was detected. TLR continued to be lower among patients receiving DES.
Authors:
Lisette Okkels Jensen; Hans Henrik Tilsted; Per Thayssen; Anne Kaltoft; Michael Maeng; Jens Flensted Lassen; Knud Noerregaard Hansen; Morten Madsen; Jan Ravkilde; Søren Paaske Johnsen; Henrik Toft Sørensen; Leif Thuesen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  5     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  898-905     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Odense University Hospital, Denmark. okkels@dadlnet.dk <okkels@dadlnet.dk>
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects,  instrumentation*,  mortality
Cardiovascular Agents / administration & dosage*
Chi-Square Distribution
Coronary Artery Disease / mortality,  therapy*
Denmark / epidemiology
Drug-Eluting Stents*
Female
Follow-Up Studies
Humans
Incidence
Kaplan-Meiers Estimate
Male
Metals*
Middle Aged
Myocardial Infarction / etiology
Paclitaxel / administration & dosage*
Platelet Aggregation Inhibitors / therapeutic use
Proportional Hazards Models
Prosthesis Design
Registries
Risk Assessment
Risk Factors
Sirolimus / administration & dosage*
Stents*
Thrombosis / etiology*,  mortality
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Metals; 0/Platelet Aggregation Inhibitors; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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