Document Detail


Paclitaxel-eluting stent long-term outcomes in percutaneous saphenous vein graft interventions (PELOPS) study.
MedLine Citation:
PMID:  19121436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the 1-year clinical and angiographic follow-up results of implantation of paclitaxel-eluting stents (PES) in aortocoronary saphenous vein graft (SVG) lesions. Sixty-eight consecutive patients with 90 nonoccluded SVG lesions were treated with PES (Taxus), size ranging from 2.25 to 4.5 mm. Angiographic follow-up was performed on 63 patients (93%) and 83 lesions (92%) at 12 months; major adverse cardiac event (MACE) was recorded in all patients at 1 year. The mean age of patients was 71+/-8 years with predominance of men (75%); the mean graft age was 13+/-4 years. Glycoprotein IIb/ IIIa inhibitors were given in 21 patients (31%); embolic protection devices were used in 54 lesions (60%). On average, patients received 1.4 stents per lesion with a stent size of 3.4+/-0.6 mm and a length of 35.8+/-27.0 mm. Angiographic follow-up revealed a late loss of 0.36+/-0.66 mm with an in-segment binary restenosis rate of 7%. The in-hospital MACE was 7%, which was solely contributed by 5 patients with postprocedure non-Q myocardial infarction; the 1-year MACE was 15%, accounted by 1 noncardiac death and 9 patients with target vessel revascularization. Peripheral vascular disease and the use of glycoprotein IIb/ IIIa inhibitors were the independent predictors of MACE at 1 year. In conclusion, implantation of PES to treat degenerative aortocoronary SVG lesions is safe and associated with low late loss, angiographic restenosis, and MACE at 1-year follow-up.
Authors:
Man Hong Jim; Hee Hwa Ho; Ryan Lap-yan Ko; Kai Hang Yiu; Chung Wah Siu; Chu Pak Lau; Wing Hing Chow
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Publication Detail:
Type:  Journal Article     Date:  2008-10-30
Journal Detail:
Title:  The American journal of cardiology     Volume:  103     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-02-10     Revised Date:  2009-04-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-202     Citation Subset:  AIM; IM    
Affiliation:
Cardiac Medical Unit, Grantham Hospital, Hong Kong. jimmanh2002@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Angiography
Coronary Artery Bypass*
Coronary Disease / radiography,  therapy*
Drug-Eluting Stents*
Female
Humans
Logistic Models
Male
Paclitaxel / administration & dosage*
Proportional Hazards Models
Prospective Studies
Saphenous Vein / transplantation*
Treatment Outcome
Tubulin Modulators / administration & dosage*
Chemical
Reg. No./Substance:
0/Tubulin Modulators; 33069-62-4/Paclitaxel
Comments/Corrections
Comment In:
Am J Cardiol. 2009 Apr 1;103(7):1042-3   [PMID:  19327440 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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