Document Detail


Paclitaxel drug delivery systems.
MedLine Citation:
PMID:  23289542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Paclitaxel (PTX) is one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers. However, its clinical application has been limited due to its poor water solubility. Its current clinical administration uses the adjuvant of serious side effects and has undesired pharmacokinetics and biodistribution. There is, thus, a need for the development of alternate drug delivery systems of PTX to enhance its solubility, permeability and stability and further to promote a sustained, controlled and targeted delivery that will increase its therapeutic effects and reduce its side effects.
AREAS COVERED: This review is focused on recent developments of the various PTX delivery systems such as prodrugs, micelles, liposomes, solid lipid nanoparticles, nanoparticles of biodegradable polymers, dendrimers, nanohydrogels, as well as PTX-eluting stents.
EXPERT OPINION: Pharmaceutical nanotechnology can provide solutions to solve the problems encountered in drug formulation and drug delivery and may change the way drugs are made. The various nanocarriers could have high efficiency in drug encapsulation and cellular uptake, escape from elimination by microphages due to their appropriate size and surface modification and realize with ligand conjugation-targeted delivery.
Authors:
Zhiping Zhang; Lin Mei; Si-Shen Feng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-06
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-05-20     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-40     Citation Subset:  IM    
Affiliation:
Huazhong University of Science & Technology, Tongji School of Pharmacy and National Engineering Research Center for Nanomedicine, Wuhan 430030, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / administration & dosage*
Chemistry, Pharmaceutical
Drug Compounding
Drug Delivery Systems*
Humans
Nanomedicine
Paclitaxel / administration & dosage*
Solubility
Tissue Distribution
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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