Document Detail


Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case report and literature review.
MedLine Citation:
PMID:  25114574     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports. Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.
Authors:
Ying Li; Yanping Li; Junyu Li; Guoliang Pi; Wenyong Tan
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Publication Detail:
Type:  Journal Article     Date:  2014-07-31
Journal Detail:
Title:  OncoTargets and therapy     Volume:  7     ISSN:  1178-6930     ISO Abbreviation:  Onco Targets Ther     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-12     Completed Date:  2014-08-12     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101514322     Medline TA:  Onco Targets Ther     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  1361-6     Citation Subset:  -    
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