Document Detail

Paclitaxel and carboplatin chemotherapy administered during pregnancy for advanced epithelial ovarian cancer.
MedLine Citation:
PMID:  14607056     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ovarian cancer diagnosed during pregnancy is uncommon. Most chemotherapy use reported has been in combination with cisplatinum. Paclitaxel in combination with carboplatin during pregnancy has not yet been reported. CASE: A right adnexal mass was diagnosed during pregnancy at 5 weeks' gestational age in a 30-year-old woman. A laparotomy was performed 2 1/2 weeks later because of the worsening nature of her symptoms and the possibility of ovarian torsion. At surgery, the patient was diagnosed with stage IIIC ovarian papillary serous cystadenocarcinoma. She was treated with six cycles of paclitaxel and carboplatin beginning at 16-17 weeks' gestation. At 35.5 weeks' gestation, a cesarean hysterectomy, left salpingo-oophorectomy, and pelvic and paraaortic nodal sampling with multiple peritoneal biopsies was performed without incident. However, the patient had refractory disease present in the remaining ovary. She was treated with further chemotherapy and is currently doing well. The patient experienced no adverse reactions during her treatment, and the infant has normal growth and development at 15 months of age. CONCLUSION: Paclitaxel used in combination with carboplatin for the treatment of ovarian cancer during pregnancy caused no adverse effects in the infant.
Luis E Méndez; Antoaneta Mueller; Emery Salom; Víctor Hugo González-Quintero
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  102     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2003-12-23     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1200-2     Citation Subset:  AIM; IM    
Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University of Miami School of Medicine/Jackson Memorial Medical Center, Miami, Florida 33136, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carboplatin / administration & dosage
Combined Modality Therapy
Cystadenocarcinoma, Serous / drug therapy*,  pathology,  surgery
Ovarian Neoplasms / drug therapy*,  pathology,  surgery
Paclitaxel / administration & dosage
Pregnancy Complications, Neoplastic / drug therapy*,  pathology,  surgery
Reg. No./Substance:
33069-62-4/Paclitaxel; 41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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