Document Detail


Packed column supercritical fluid chromatography of sodium stearyl fumarate aqueous suspension.
MedLine Citation:
PMID:  16174559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method for the determination of sodium stearyl fumarate aqueous suspension is described. This straightforward method is based on homogenisation of the sample, dilution of a known aliquot with methanol to a suitable clear solution and mixing with an internal standard; (S)-naproxen. Separation and quantification is performed by packed column supercritical fluid chromatography on a commercial tartaric acid network polymeric column (tertbutylbenzoyl) with UV-detection at 214 nm. The precision of the presented method upon repeated analysis of a 20 mg/ml suspension is 0.5% (n = 8), and the yield is near 100%. Less than 5 min is required for the chromatographic separation with a resolution of about 3 to the internal standard. With some modification of the chromatographic conditions water samples can also be analysed.
Authors:
Olle Gyllenhaal
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Publication Detail:
Type:  Journal Article     Date:  2005-09-19
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  40     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2007-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  971-4     Citation Subset:  IM    
Affiliation:
Analytical Development, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. olle.gyllenhaal@astrazeneca.com
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Supercritical Fluid / methods*
Excipients / analysis*,  chemistry
Fumarates / analysis*,  chemistry
Methanol
Reproducibility of Results
Spectrophotometry, Ultraviolet
Suspensions
Water
Chemical
Reg. No./Substance:
0/Excipients; 0/Fumarates; 0/Suspensions; 0/sodium stearyl fumarate; 67-56-1/Methanol; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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