| Pachydermia is not diagnostic of active laryngopharyngeal reflux disease. | |
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MedLine Citation:
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PMID: 15475781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the change in pachydermia/posterior commissure hypertrophy in patients with laryngopharyngeal reflux disease (LPR) on long-term acid-suppressive therapy. STUDY DESIGN: Retrospective chart review. METHODS: Seventeen patients with LPR who were compliant with long-term acid-suppressive treatment and had good control of their symptoms for at least 20 months were examined. Pre- and posttreatment still laryngeal images from these patients were analyzed by five otolaryngologists blinded to patient information and were scored for pachydermia/posterior commissure hypertrophy according to the Reflux Finding Score (RFS) subset. Test-retest intraobserver reliability, intergrader correlations, as well as a paired t test for means of the data sets were then calculated. RESULTS: There was no significant difference in the grading scores between the pre- and posttreatment group for degree of pachydermia/posterior commissure hypertrophy despite a prolonged treatment interval (mean = 32 months) (P = .25). CONCLUSIONS: There is no statistically significant difference in the degree of pachydermia/posterior commissure hypertrophy found at diagnosis and after long-term acid suppressive therapy in patients with LPR. Therefore, it appears that pachydermia, as an isolated finding, is unreliable in determining the presence of active LPR. |
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Authors:
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R Keith Hill; C Blake Simpson; Ruben Velazquez; Nicole Larson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 114 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-10-11 Completed Date: 2004-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 1557-61 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology/Head and Neck Surgery, University of Texas Health Science Center, San Antonio, TX, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Adult Aged Aged, 80 and over Anti-Ulcer Agents / therapeutic use Benzimidazoles / therapeutic use Drug Therapy, Combination Female Gastric Acidity Determination Gastroesophageal Reflux / diagnosis*, drug therapy Humans Hypertrophy Laryngeal Diseases / diagnosis*, drug therapy Laryngeal Mucosa / drug effects, pathology* Laryngoscopy* Long-Term Care Male Middle Aged Omeprazole / analogs & derivatives*, therapeutic use Pharyngeal Diseases / diagnosis*, drug therapy Proton Pumps / antagonists & inhibitors Retrospective Studies Sulfoxides / therapeutic use Treatment Outcome Voice Disorders / drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Proton Pumps; 0/Sulfoxides; 102625-70-7/pantoprazole; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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