Document Detail

Pachydermia is not diagnostic of active laryngopharyngeal reflux disease.
MedLine Citation:
PMID:  15475781     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the change in pachydermia/posterior commissure hypertrophy in patients with laryngopharyngeal reflux disease (LPR) on long-term acid-suppressive therapy.
STUDY DESIGN: Retrospective chart review.
METHODS: Seventeen patients with LPR who were compliant with long-term acid-suppressive treatment and had good control of their symptoms for at least 20 months were examined. Pre- and posttreatment still laryngeal images from these patients were analyzed by five otolaryngologists blinded to patient information and were scored for pachydermia/posterior commissure hypertrophy according to the Reflux Finding Score (RFS) subset. Test-retest intraobserver reliability, intergrader correlations, as well as a paired t test for means of the data sets were then calculated.
RESULTS: There was no significant difference in the grading scores between the pre- and posttreatment group for degree of pachydermia/posterior commissure hypertrophy despite a prolonged treatment interval (mean = 32 months) (P = .25).
CONCLUSIONS: There is no statistically significant difference in the degree of pachydermia/posterior commissure hypertrophy found at diagnosis and after long-term acid suppressive therapy in patients with LPR. Therefore, it appears that pachydermia, as an isolated finding, is unreliable in determining the presence of active LPR.
R Keith Hill; C Blake Simpson; Ruben Velazquez; Nicole Larson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  114     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2004-10-22     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1557-61     Citation Subset:  IM    
Department of Otolaryngology/Head and Neck Surgery, University of Texas Health Science Center, San Antonio, TX, USA.
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MeSH Terms
Aged, 80 and over
Anti-Ulcer Agents / therapeutic use
Benzimidazoles / therapeutic use
Drug Therapy, Combination
Gastric Acidity Determination
Gastroesophageal Reflux / diagnosis*,  drug therapy
Laryngeal Diseases / diagnosis*,  drug therapy
Laryngeal Mucosa / drug effects,  pathology*
Long-Term Care
Middle Aged
Omeprazole / analogs & derivatives*,  therapeutic use
Pharyngeal Diseases / diagnosis*,  drug therapy
Proton Pumps / antagonists & inhibitors
Retrospective Studies
Sulfoxides / therapeutic use
Treatment Outcome
Voice Disorders / drug therapy,  etiology*
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Proton Pumps; 0/Sulfoxides; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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