Document Detail

Pacemaker current exists in ventricular myocytes.
MedLine Citation:
PMID:  7678078     Owner:  NLM     Status:  MEDLINE    
I(f), the "cardiac pacemaker current," is a nonselective cation channel activated on hyperpolarization in primary and secondary pacemaker regions of the mammalian heart. The cardiac pacing rate can be modulated by shifting the activation of I(f) to more positive (faster pacing) or more negative (slower pacing) voltages. We report for the first time the presence of this pacemaker current in ventricular myocytes. The potential importance of this observation to the mechanism of differentiation of nonpacing regions in the heart is discussed.
H Yu; F Chang; I S Cohen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  72     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-01-29     Completed Date:  1993-01-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  IM    
Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661.
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MeSH Terms
Cations / metabolism
Guinea Pigs
Heart Conduction System / physiology*
Ion Channels / physiology*
Myocardium / cytology
Purkinje Fibers / physiology
Ventricular Function*
Grant Support
Reg. No./Substance:
0/Cations; 0/Ion Channels

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