| Pacemaker current exists in ventricular myocytes. | |
| | |
MedLine Citation:
|
PMID: 7678078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
I(f), the "cardiac pacemaker current," is a nonselective cation channel activated on hyperpolarization in primary and secondary pacemaker regions of the mammalian heart. The cardiac pacing rate can be modulated by shifting the activation of I(f) to more positive (faster pacing) or more negative (slower pacing) voltages. We report for the first time the presence of this pacemaker current in ventricular myocytes. The potential importance of this observation to the mechanism of differentiation of nonpacing regions in the heart is discussed. |
| | |
Authors:
|
H Yu; F Chang; I S Cohen |
Related Documents
:
|
19111428 - External monitoring-induced pacemaker-driven tachycardia: a case report. 9392808 - The combined transvenous implantation of cardioverter defibrillators and permanent pace... 1199808 - Treatment of sinoatrial syndrome with permanent cardiac pacing in 90 patients. 10588158 - Feasibility of pacemaker therapy after dynamic cardiomyoplasty. 6981998 - Temporal dependence of beneficial effects of coronary thrombolysis characterized by pos... 6881358 - Myoglobin oxygenation remains constant during the cardiac cycle. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 72 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1993 Jan |
Date Detail:
|
Created Date: 1993-01-29 Completed Date: 1993-01-29 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 232-6 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Biophysics, SUNY Stony Brook 11794-8661. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cations / metabolism Dogs Electrophysiology Guinea Pigs Heart Conduction System / physiology* Ion Channels / physiology* Myocardium / cytology Purkinje Fibers / physiology Ventricular Function* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-20558/HL/NHLBI NIH HHS; HL-28958/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cations; 0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel cation-selective mechanosensitive ion channel in the atrial cell membrane.
Next Document: Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary a...