Document Detail


PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.
MedLine Citation:
PMID:  22252826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Artemisinins induce drug metabolism through the activation of the pregnane X receptor (PXR) in vitro. Here, we report the resequencing and genotyping of PXR variants in 75 Vietnamese individuals previously characterized for CYP3A enzyme activity after artemisinin exposure. We identified a total of 31 PXR variants, including 5 novel single nucleotide polymorphisms (SNPs), and we identified significantly different allele frequencies relative to other ethnic groups. A trend of significance was observed between the level of CYP3A4 induction by artemisinin and two PXR variants, the 8118C→T (Y328Y) and 10719A→G variants.
Authors:
Rita Piedade; Elke Schaeffeler; Stefan Winter; Sara Asimus; Matthias Schwab; Michael Ashton; Oliver Burk; José P Gil
Related Documents :
22209986 - Transforming growth factor-β1 gene +869t/c, but not +915g/c polymorphism is associated ...
21585586 - Evidence of multiple paternity and mate selection for inbreeding avoidance in wild east...
21951716 - Simulating natural selection in landscape genetics.
21585896 - Isolation and characterization of microsatellite markers for casearia sylvestris sw. (s...
8935316 - Genetic structure in relation to the history of hungarian ethnic groups.
22121826 - Novel α2 gene deletion (c.349_359 del gagttcacccc) identified in association with the -...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-17
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2153-7     Citation Subset:  IM    
Affiliation:
Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. rita.piedade@ki.se
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
Alleles
Antimalarials / pharmacology*
Artemisinins / pharmacology*
Cytochrome P-450 CYP3A / biosynthesis*,  genetics
DNA Primers
Enzyme Induction / drug effects
Gene Frequency
Genetic Variation
Humans
Pharmaceutical Preparations / metabolism
Polymorphism, Single Nucleotide
Receptors, Steroid / drug effects,  genetics*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Vietnam / epidemiology
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Antimalarials; 0/Artemisinins; 0/DNA Primers; 0/Pharmaceutical Preparations; 0/Receptors, Steroid; 0/pregnane X receptor; 9RMU91N5K2/artemisinine; EC 1.14.14.1/Cytochrome P-450 CYP3A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics of and short-term virologic response to low-dose 400-milligram once-daily raltegrav...
Next Document:  A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tubercul...