Document Detail

PVN Modulates Thyroidal Motilin Release which Modulates Rat Gastric Motility.
MedLine Citation:
PMID:  21756270     Owner:  NLM     Status:  Publisher    
Motilin, an important endocrine regulator of gastrointestinal motility, was once believed to have been produced in the gastrointestinal tract and brain. In recent years, however, motilin was found in the human thyroid as well as in that of the guinea pig. The physiological function and central modulation of thyroidal motilin are still poorly understood. To determine the functional role of thyroidal motilin, we observed the concentration of motilin in plasma and the gastric motility before and after a thyroidectomy. Our studies showed that both the concentration of plasma motilin and gastric motility were decreased after the thyroidectomy. To explore modulation related nuclei, the c-Fos immune response experiment was carried out. The paraventricular nucleus (PVN) of the hypothalamus was the main reacting area after the thyroidectomy. Subsequently, we studied the effects of electric excitation and lesions of the PVN on gastric motility and the expression of motilin in the thyroid and plasma. It showed that excitation of PVN could prompt gastric motility that was partly prevented by the motilin receptor antagonist, GM-109. The effects of PVN excitation on gastric contraction were significantly reduced in thyroidectomized rats. In addition, the expression of motilin in the thyroid was significantly increased after the PVN excitation and decreased after the lesions of the PVN. The changes in the concentration of motilin in plasma induced by the PVN stimulation were positively correlated with the changes of gastric motility. In our in vitro study, the motilin secreted from TT cells (a parafollicular cell line originating from human thyroid medullary carcinoma) gradually increased on the sixth day of culture, and motilin and calcitonin (CT) were co-expressed in TT cells. These results demonstrated that motilin from the thyroid could be secreted into the peripheral plasma to affect the gastric motility and that PVN was a central nucleus that modulated gastric motility and motilin expression in the thyroid.
Feifei Guo; Luo Xu; Xiangrong Sun; Shengli Gao; Hai Zhu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-14
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neuroendocrinology © 2011 Blackwell Publishing.
Department of Pathophysiology, Medical College of Qingdao University, Qingdao, Shandong 266021, PR China.
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