| PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study. | |
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MedLine Citation:
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PMID: 113025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Repigmentation induced by oral photochemotherapy (8-MOP + UV-A) in four patients with vitiligo has been studied by histochemical and ultrastructural techniques. Hypertrophic melanocytes were demonstrated both in the middle and deep portions of the hair follicles in the centre of islands of repigmentation and also in the epidermis of the expanding repigmenting border. Mitosis of melanocytes was absent in these areas. Ultrastructural study showed that the melanocytes of repigmented areas were hyperactive. The melanosomes were larger than those of surrounding healthy skin, although the mode of packaging was unaltered. These observations suggest that melanocytes repigmenting vitiliginous skin under the influence of oral photochemotherapy are derived from a melanocytic reservoir localized in the hair follicles. |
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Authors:
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J P Ortonne; D M MacDonald; A Micoud; J Thivolet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 101 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-11-28 Completed Date: 1979-11-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Count Dihydroxyphenylalanine Female Histocytochemistry Humans Male Melanocytes / enzymology, ultrastructure Methoxsalen / therapeutic use Microscopy, Electron Monophenol Monooxygenase / metabolism Photochemotherapy* Skin / ultrastructure Skin Pigmentation* / drug effects Vitiligo / drug therapy, enzymology, pathology* |
| Chemical | |
Reg. No./Substance:
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298-81-7/Methoxsalen; 63-84-3/Dihydroxyphenylalanine; EC 1.14.18.1/Monophenol Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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