Document Detail

PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study.
MedLine Citation:
PMID:  113025     Owner:  NLM     Status:  MEDLINE    
Repigmentation induced by oral photochemotherapy (8-MOP + UV-A) in four patients with vitiligo has been studied by histochemical and ultrastructural techniques. Hypertrophic melanocytes were demonstrated both in the middle and deep portions of the hair follicles in the centre of islands of repigmentation and also in the epidermis of the expanding repigmenting border. Mitosis of melanocytes was absent in these areas. Ultrastructural study showed that the melanocytes of repigmented areas were hyperactive. The melanosomes were larger than those of surrounding healthy skin, although the mode of packaging was unaltered. These observations suggest that melanocytes repigmenting vitiliginous skin under the influence of oral photochemotherapy are derived from a melanocytic reservoir localized in the hair follicles.
J P Ortonne; D M MacDonald; A Micoud; J Thivolet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  101     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
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MeSH Terms
Cell Count
Melanocytes / enzymology,  ultrastructure
Methoxsalen / therapeutic use
Microscopy, Electron
Monophenol Monooxygenase / metabolism
Skin / ultrastructure
Skin Pigmentation* / drug effects
Vitiligo / drug therapy,  enzymology,  pathology*
Reg. No./Substance:
298-81-7/Methoxsalen; 63-84-3/Dihydroxyphenylalanine; EC Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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