Document Detail

PUVA-induced blisters, complement deposition, and damage to the dermoepidermal junction.
MedLine Citation:
PMID:  3314716     Owner:  NLM     Status:  MEDLINE    
We followed the course of 56 patients receiving psoralen plus long-wave ultraviolet light (PUVA) therapy. Nonhemorrhagic blisters developed on clinically normal skin on the limbs of seven patients. Seeming to be related to friction and trauma, the blisters form as a result of damage to the basal and suprabasal layers. Perilesional skin specimens from all blistered patients contained granular deposits of C3 at the dermoepidermal junction, around the upper dermal blood vessels, or at both sites. The average time for initiation and complete formation of suction blisters was measured in 51 patients at different stages during the course of PUVA treatment. Blister separation was in the lamina lucida, with the pemphigoid antigen in the roof while the blister floor contained the lamina densa, laminin, and type IV collagen. This impaired dermoepidermal adhesion was a general phenomenon that occurred in all PUVA-treated patients. The mechanism remains to be determined.
P S Friedmann; P Coburn; M G Dahl; B L Diffey; J Ross; G P Ford; S C Parker; P Bird
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  123     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-11-27     Completed Date:  1987-11-27     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1471-7     Citation Subset:  AIM; IM    
Department of Dermatology, University of Newcastle-Upon-Tyne, England.
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MeSH Terms
Blister / etiology*,  pathology
Complement C3 / immunology*
Epidermis / drug effects
Fluorescent Antibody Technique
PUVA Therapy / adverse effects*
Skin / immunology*,  pathology
Reg. No./Substance:
0/Complement C3

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