Document Detail


PTRcombiner: mining combinatorial regulation of gene expression from post-transcriptional interaction maps.
MedLine Citation:
PMID:  24758252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The progress in mapping RNA-protein and RNA-RNA interactions at the transcriptome-wide level paves the way to decipher possible combinatorial patterns embedded in post-transcriptional regulation of gene expression.
RESULTS: Here we propose an innovative computational tool to extract clusters of mRNA trans-acting co-regulators (RNA binding proteins and non-coding RNAs) from pairwise interaction annotations. In addition the tool allows to analyze the binding site similarity of co-regulators belonging to the same cluster, given their positional binding information. The tool has been tested on experimental collections of human and yeast interactions, identifying modules that coordinate functionally related messages.
CONCLUSIONS: This tool is an original attempt to uncover combinatorial patterns using all the post-transcriptional interaction data available so far. PTRcombiner is available at http://disi.unitn.it/~passerini/software/PTRcombiner/.
Authors:
Gianluca Corrado; Toma Tebaldi; Giulio Bertamini; Fabrizio Costa; Alessandro Quattrone; Gabriella Viero; Andrea Passerini
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-23
Journal Detail:
Title:  BMC genomics     Volume:  15     ISSN:  1471-2164     ISO Abbreviation:  BMC Genomics     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965258     Medline TA:  BMC Genomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  304     Citation Subset:  -    
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