Document Detail

PTP1B inhibitors from Ardisia japonica.
MedLine Citation:
PMID:  15621596     Owner:  NLM     Status:  MEDLINE    
In bioassay-directed isolation from the whole plant of Ardisia japonica, sixteen known compounds: chrysophanol (1), physcion (2), oleanolic acid (3), euscaphic acid (4), tormentic acid (5), quercetin (6), quercitrin (7), myricitrin (8), kaempferol 3-O-alpha-L-rhamnopyranoside (9), cyclamiretin A 3-O-alpha--rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->2)-[beta-D-glucopyranosyl(1-->4)]-alpha-L-arabinopyranoside (10), (7E)-9-hydroxymegastigma-4, 7-dien-3-on-9-O-beta-D-glucopyranoside (11), bergenin (12), norbergenin (13), rutin (14), kaempferol 3,7-O-alpha-L-dirhamnopyranoside (15), (-)-epigallacatechin 3-O-gallate (16) were obtained. Compounds 1-5, 9, 11 and 14-16 have not been reported previously from this plant. Among these isolates, 2, 3, 6 and 12 showed moderate bioactivity against PTP1B in vitro with IC50 values of 121.50, 23.90, 28.12 and 157 microM, respectively.
Yan-Fang Li; Li-Hong Hu; Feng-Chang Lou; Jia Li; Qiang Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  7     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-03-11     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai, China.
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MeSH Terms
Ardisia / chemistry*
Enzyme Inhibitors / chemistry,  isolation & purification*
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Reg. No./Substance:
0/Enzyme Inhibitors; EC Tyrosine Phosphatase, Non-Receptor Type 1; EC Tyrosine Phosphatases

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