| PTK7: a cell polarity receptor with multiple facets. | |
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MedLine Citation:
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PMID: 21415598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PTK7 is a tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels. Loss of function of PTK7 leads to profound morphogenetic defects in the mouse, such as neural tube defects, misorientation of stereocilia in the inner ear, and impaired polarized cell movements. The planar cell polarity pathway is classically assigned to a non-canonical Wnt pathway, which does not rely on b-catenin transcriptional activity. We recently revealed that PTK7 is implicated in b-catenin-dependent developmental processes in mammalian and Xenopus systems. Based on data recently obtained by our group as well as others, we discuss how PTK7 could be involved in canonical and non-canonical Wnt pathways, and which implications are expected from these data in physiology and physiopathology. |
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Authors:
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Anne-Catherine Lhoumeau; Francesca Puppo; Thomas Prébet; Laurent Kodjabachian; Jean-Paul Borg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-15 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 10 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-31 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1233-6 Citation Subset: IM |
Affiliation:
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INSERM U891, Centre de Recherche en Cancérologie de Marseille, Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement Cell Polarity Gene Expression Regulation, Developmental Humans Mice Neural Tube / cytology, embryology, metabolism* Neural Tube Defects / genetics, metabolism*, physiopathology Neurogenesis / genetics Receptor Protein-Tyrosine Kinases* / genetics, metabolism Signal Transduction / physiology Wnt Proteins / genetics, metabolism* Xenopus Proteins / genetics, metabolism Xenopus laevis beta Catenin / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Catnb protein, mouse; 0/Wnt Proteins; 0/Xenopus Proteins; 0/beta Catenin; 0/beta-catenin protein, Xenopus; EC 2.7.10.1/PTK7 protein, Xenopus; EC 2.7.10.1/Ptk7 protein, mouse; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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