Document Detail


PTK7: a cell polarity receptor with multiple facets.
MedLine Citation:
PMID:  21415598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PTK7 is a tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels. Loss of function of PTK7 leads to profound morphogenetic defects in the mouse, such as neural tube defects, misorientation of stereocilia in the inner ear, and impaired polarized cell movements. The planar cell polarity pathway is classically assigned to a non-canonical Wnt pathway, which does not rely on b-catenin transcriptional activity. We recently revealed that PTK7 is implicated in b-catenin-dependent developmental processes in mammalian and Xenopus systems. Based on data recently obtained by our group as well as others, we discuss how PTK7 could be involved in canonical and non-canonical Wnt pathways, and which implications are expected from these data in physiology and physiopathology.
Authors:
Anne-Catherine Lhoumeau; Francesca Puppo; Thomas Prébet; Laurent Kodjabachian; Jean-Paul Borg
Related Documents :
6929488 - Induction of pyruvate carboxylase apoenzyme and holoenzyme in 3t3-l1 cells during diffe...
3169158 - Morphological changes in erythroblasts during erythropoietin-induced terminal different...
15019158 - Brusatol-induced hl-60 cell differentiation involves nf-kappab activation.
6832228 - Nucleolus-like bodies in embryonal carcinoma cells of the embryoid bodies isolated from...
4000168 - X-ray induction of 6-thioguanine-resistant mutants in division arrested, g0/g1 phase ch...
2172058 - Clonal analysis of the cell lineages in the male flower of maize.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-15
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-31     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1233-6     Citation Subset:  IM    
Affiliation:
INSERM U891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Cell Polarity
Gene Expression Regulation, Developmental
Humans
Mice
Neural Tube / cytology,  embryology,  metabolism*
Neural Tube Defects / genetics,  metabolism*,  physiopathology
Neurogenesis / genetics
Receptor Protein-Tyrosine Kinases* / genetics,  metabolism
Signal Transduction / physiology
Wnt Proteins / genetics,  metabolism*
Xenopus Proteins / genetics,  metabolism
Xenopus laevis
beta Catenin / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Catnb protein, mouse; 0/Wnt Proteins; 0/Xenopus Proteins; 0/beta Catenin; 0/beta-catenin protein, Xenopus; EC 2.7.10.1/PTK7 protein, Xenopus; EC 2.7.10.1/Ptk7 protein, mouse; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A breathtaking phenotype: unexpected roles of the DNA base damage response protein ASCIZ as a key re...
Next Document:  Arginine Decarboxylase expression, polyamines biosynthesis and reactive oxygen species during organo...