Document Detail

PTK7: a cell polarity receptor with multiple facets.
MedLine Citation:
PMID:  21415598     Owner:  NLM     Status:  MEDLINE    
PTK7 is a tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels. Loss of function of PTK7 leads to profound morphogenetic defects in the mouse, such as neural tube defects, misorientation of stereocilia in the inner ear, and impaired polarized cell movements. The planar cell polarity pathway is classically assigned to a non-canonical Wnt pathway, which does not rely on b-catenin transcriptional activity. We recently revealed that PTK7 is implicated in b-catenin-dependent developmental processes in mammalian and Xenopus systems. Based on data recently obtained by our group as well as others, we discuss how PTK7 could be involved in canonical and non-canonical Wnt pathways, and which implications are expected from these data in physiology and physiopathology.
Anne-Catherine Lhoumeau; Francesca Puppo; Thomas Prébet; Laurent Kodjabachian; Jean-Paul Borg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-15
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-31     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1233-6     Citation Subset:  IM    
INSERM U891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
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MeSH Terms
Cell Movement
Cell Polarity
Gene Expression Regulation, Developmental
Neural Tube / cytology,  embryology,  metabolism*
Neural Tube Defects / genetics,  metabolism*,  physiopathology
Neurogenesis / genetics
Receptor Protein-Tyrosine Kinases* / genetics,  metabolism
Signal Transduction / physiology
Wnt Proteins / genetics,  metabolism*
Xenopus Proteins / genetics,  metabolism
Xenopus laevis
beta Catenin / genetics,  metabolism
Reg. No./Substance:
0/Catnb protein, mouse; 0/Wnt Proteins; 0/Xenopus Proteins; 0/beta Catenin; 0/beta-catenin protein, Xenopus; EC protein, Xenopus; EC protein, mouse; EC Protein-Tyrosine Kinases

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