| PTEN modulators: a patent review. | |
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MedLine Citation:
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PMID: 23379765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: PTEN (phosphatase and tensin homolog deleted on chromosome 10) plays a pivotal role in controlling intracellular signaling for cell survival and proliferation by inhibiting the PI3K/Akt pathway, and its dysfunction is associated with several neoplastic diseases. PTEN is frequently found mutated in many pathological conditions highlighting its importance in normal physiological function. Unlike several cellular proteins which are activated by phosphorylation, PTEN is inactivated upon phosphorylation by specific kinases which phosphorylate serine and threonine residues in its C-terminal region. Therefore, development of therapeutic agents that specifically target kinases and kinase-domain-containing proteins affecting PTEN would lead to the treatment of PTEN-related diseases. Areas covered: With increasing evidence on the role of PTEN in many human diseases, the present review focuses on the clinical relevance of PTEN with a comprehensive list of currently identified modulators of PTEN, and proposes potentially novel molecular targets which could aid in the development of drug candidates for the treatment of PTEN-related diseases such as cardiovascular diseases, diabetes, obesity, cancer, autism, Parkinson's and Alzheimer's diseases. Expert opinion: This review describes several target sites that could help in the development of novel drug candidates to regulate or restore the normal physiological functions of PTEN and are essential in the treatment of human diseases where PTEN plays a pivotal role. |
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Authors:
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Chandra S Boosani; Devendra K Agrawal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-5 |
Journal Detail:
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Title: Expert opinion on therapeutic patents Volume: - ISSN: 1744-7674 ISO Abbreviation: Expert Opin Ther Pat Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516419 Medline TA: Expert Opin Ther Pat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Creighton University School of Medicine, Department of Biomedical Sciences , CRISS II Room 510, 2500 California Plaza, Omaha, NE 68178 , USA +1 402 280 2938 ; +1 402 280 1421 ; DevendraAgrawal@creighton.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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