| PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice. | |
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MedLine Citation:
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PMID: 17728018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutations in presenilin (PS) genes cause majority of early onset Alzheimer's disease (AD), an age related neurodegenerative disorder. PS proteins undergo proteolytic cleavage to produce biologically active fragments, which constitute the catalytic core of the gamma-secretase enzyme. This enzyme cleaves beta-amyloid precursor protein (betaAPP) to generate Abeta peptides, which are influenced by sex steroids. Recently we have reported the downregulation of PS1 expression by sex steroids in the brain of adult mice. Here we have examined the effect of gonadectomy and subsequent administration of gonadal hormones 17beta-estradiol and testosterone on the level of PS2 C-terminal fragment (CTF) in the cerebral cortex of adult and old AKR strain mice of both sexes. PS2 expression was downregulated following gonadectomy, but upregulated by supplementation of gonadal steroids in both age groups and sexes. Thus these results demonstrate up-regulation of PS2 protein expression by sex steroids, which in turn may influence PS2 associated brain functions. |
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Authors:
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Soumi Ghosh; M K Thakur |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-24 |
Journal Detail:
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Title: Neurochemistry international Volume: 52 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 363-7 Citation Subset: IM |
Affiliation:
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Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism*,
pathology Alzheimer Disease / metabolism*, physiopathology Amyloid Precursor Protein Secretases / metabolism Amyloid beta-Protein / metabolism Amyloid beta-Protein Precursor / metabolism Animals Cerebral Cortex / drug effects, metabolism*, physiopathology Disease Models, Animal Estradiol / metabolism, pharmacology Female Gonadal Steroid Hormones / metabolism*, pharmacology Male Mice Orchiectomy Ovariectomy Presenilin-2 / metabolism* Sex Characteristics Testosterone / metabolism Up-Regulation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Amyloid beta-Protein Precursor; 0/Gonadal Steroid Hormones; 0/Presenilin-2; 50-28-2/Estradiol; 58-22-0/Testosterone; EC 3.4.-/Amyloid Precursor Protein Secretases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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