| PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety. | |
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MedLine Citation:
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PMID: 19576924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To address the development of early anxiety disorders across the lifespan, the High USV line of rats was bred based on rates of infant ultrasonic vocalization in the 40-50 kHz range of predominant frequencies (USV) to maternal separation at postnatal day (P) 10. In this study, rates of USV in High line infants (pups: Postnatal Day 11+/-1) were compared to those of randomly-bred controls in response to EPIX compound PRX-00023, a unique serotonin (5-HT) agonist, acting exclusively at the 5-HT1A receptor, or buspirone, a nonspecific 5HT1A agonist. After testing, pups were examined for sedation and other drug-related effects. The results indicated that all doses of buspirone reduced USV rates in isolation, consistent with other reports. PRX-00023 significantly reduced USV rates at the lowest doses (0.01-0.05 mg/kg). None of the PRX-00023 doses produced sedation, whereas all but the lowest dose of buspirone (0.1 mg/kg) produced sedation effects. The results suggest that this compound alleviates infantile anxiety-like behavior with great specificity in rats bred for high anxiety/depressive phenotypes by selectively targeting 5-HT1A receptors, possibly by both pre- and post-synaptic mechanisms. |
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Authors:
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Susan A Brunelli; Jessica A Aviles; Kimberly S Gannon; Aron Branscomb; Sharon Shacham |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-02 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 94 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 8-15 Citation Subset: IM |
Affiliation:
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Division of Developmental Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. sab9@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Anti-Anxiety Agents / administration & dosage, pharmacology* Anxiety / drug therapy*, genetics Anxiety Disorders / drug therapy Anxiety, Separation / drug therapy Ataxia / chemically induced Body Temperature / drug effects Buspirone / administration & dosage, pharmacology* Disease Models, Animal Dose-Response Relationship, Drug Eliminative Behavior, Animal / drug effects Female Grooming / drug effects Hybridization, Genetic Male Movement / drug effects Piperazines / administration & dosage, pharmacology* Rats Reaction Time / drug effects Receptor, Serotonin, 5-HT1A / agonists* Sex Characteristics Social Isolation Sulfonamides / administration & dosage, pharmacology* Ultrasonics Vocalization, Animal / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/N-(3-(4-(4-cyclohexylmethanesulfonylaminobutyl)piperazin-1-yl)phenyl)acetamide; 0/Piperazines; 0/Sulfonamides; 112692-38-3/Receptor, Serotonin, 5-HT1A; 36505-84-7/Buspirone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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